Diclofenac has been used (as the sodium salt) for topical treatment of AK since the 1990s (Rivers and McLean, 1997). The rationale for the use of this non-steroidal anti-inflammatory drug is the over expression of the cycloxygenase-2 enzyme in AK and SCC compared with normal cells (Buckman et al., 1998). In studies with SCC cell cultures, the commercial preparation, Solaraze™, when diluted to 0.2-0.3% was observed to promote apoptosis in certain sensitive cell lines (Fecker et al. 2010).…
Aim: Identify positive and negative colors seen from substances contacted with Marquis and Mandelin reagents Introduction: Drug location includes introductory screening of tests for medications and in restorative applications the screening tests results specifically utilized for medicinal assessment. For legitimate purposes, the screening technique takes out all negatives, positive results viewed as possible and require affirmation utilizing corroborative strategies, for example, elite fluid…
placebo-controlled trials have been conducted evaluating the efficacy of citicoline in improving the recovery in patients with acute ischemic stroke. The first study revealed citicoline to be more effective than placebo in patients with moderate to mild ischemic stroke. The following three trials by Clark et al focused on finding an effective dose and specific stroke severity scores to show the possible efficacy of citicoline. Citicoline showed very little to no benefit in these trials. The…
major Nazi criminal trials laid in the hands of the powerful Allied judges. The Nuremberg trials were legal proceedings against German Nazi former leaders for crimes committed before and during World War II. The Nuremberg trials lasted from 1945 to 1949. This tribunal presided over international war crimes for the first time in the long history of warfare (Rice 8). The Nuremberg trials started to resolve the crimes committed by Nazis during World War II. During the trials, criminals were…
Deception is at the core of the issue when using placebo drugs as a form of treatment (Benedetti, 2012). Deception has multiple definitions is this situation. However, Blease, Colloca and Kaptchuk (2016) describe deception as the act of withholding information with the intention to mislead the individual into thinking something else. Even when doctors can support the idea that the use of placebos is an effective course of treatment because the positive expectations that arises from it has the…
unorthodoxy. Plato found his interest in philosophy because of Socrates. It is the thought that Socrates directed his disciple’s studies toward the questions of virtue and how it establishes itself in the decency of human character. Plato observed the trial and execution of Socrates carried out by the Athenian democracy. Socrates was charged by the government for corrupting the youth and was hated by many for questioning the foundations…
CORRLEATION OF PERNICIOUS ANEMIA WITH HOMOCYSTEINEMIA AND HETEROZYGOUS MTHFR MUTATION HELPS DIFFERENTIATE FROM DIAGNOSIS OF THROMBOTIC THROMBOCYTOPENIC PURPURA Wu, Alex MD1, Chen, Kevin MD2, Sittambalam, Charmian MD1 1Department of Medicine, Franklin Square Medical Center, Baltimore, MD; 2Department of Hematology/Oncology, Franklin Square Medical Center, Baltimore, MD There are increasing number of recent publications that recognized the similarity between TTP and B12 deficiency, and that TTP…
Preventing Adverse Effects Decision-making support tools built into web-based EHR systems help prevent adverse events associated with drug allergies and negative drug interactions caused by food or other medications. Expeditious access to drug contraindications, patient history and pharmaceutical information enables providers to make faster decisions when prescribing or administering medication at the point of care. From a broader perspective, pertinent information recorded in a patient EHR can…
classic 1960’s Stanley Kramer-directed cinema, “Inherit the Wind”, idealizes the 1925 famous Scopes Monkey Trial in Dayton, Tennessee. The Scopes Monkey Trial was a court case about whether emerging scientific theories were allowed to be taught in the public classroom if the theories infringe the traditional religious beliefs. The overall notion in this fictional portrayal of the Scopes Monkey Trial was defending an individual’s right to think and express their own thoughts. In the film, this…
demonstrates the spectacle of the Scopes Trial because both show the persecution of those who go against the dominant trend, individuals commodify themselves, and hatred is commercialized. Oppression to those who go against the dominant trend presented in the play, reflects to the 1925 Tennessee Scopes Trial in sense of the controversial fight between religion and science. Christianity was strictly believed by majority during the settings of the Scopes Trial and there was a general lack of…