Transferrin

Haemochromatosis is a genetic disease that causes its victims to store too much iron in their body. This is a very serious problem in today’s society, yet I do not feel that there is enough recognition for it. It’s not recognized as widely as cancer, but if left untreated, it can grow to be just as serious. I believe it should be recognized as widely at cancer, because it is just as dangerous. This disease is important because it can and will do major damage to the body if left untreated.…

Hereditary fructose intolerance was first noticed and reported in an adult woman in 1956 by Chambers and Pratt (HFI). Chambers and Pratt observed that the woman started having faintness, nausea and abdominal pain after consuming fructose and sugar (HFI). However, those symptoms disappeared when the woman ate glucose instead (HFI). After a series of testings with different sugars, Chambers and Pratt believed that this woman was “idiosyncrasy to fructose”, but they never thought it would be…

"Anemia is a reduction in the total number of erythrocytes in the circulating blood or a decrease in the quality or quantity of hemoglobin" (McCance & Huether, 2014, p.982). There are many causes of anemia and are classified in this manner. There are three classifications: macrocytic-normochromic anemia, microcytic-hypochromic anemia, and normocytic-normochromic anemia (McCance & Huether, 2014). Macrocytic-normochromic anemias encompass pernicious anemia and folate deficiency anemia (McCance &…

Vulnibactin specifically uses HupA to steal iron from host transferrins and holotransferrins due to it having a higher affinity for iron, and deferoxamine promotes organism growth and iron uptake [28]. Variation between virulent and avirulent forms of V. vulnificus depends on the presence of these three virulence factors. Virulent forms are almost always encapsulated, serum resistant, and possessing the ability to acquire iron from iron-saturated transferrin, while avirulent variants lack these…

What causes iron overload? You may be asking yourself, what exactly causes hemochromatosis? The main reason that causes hereditary hemochromatosis is when a person inherits two mutated copies of the HFE gene from each parent. Both genders have the same chance of inheriting the gene Not everyone with the HFE gene develops the disease Summary and Conclusion If your body cannot maintain a healthy and regular amount of iron, you are in risk of Hemochromatosis aka Iron Storage Disease. The…

barely visible in the gel, a copy was provided in class to compare with the bands obtained in our samples. Based on the column 1, it can be observed 4 clear bands in the gel. The 4 bands observed in the gel correspond to the gamma globulin, albumin, transferrin and alpha 1 and alpha 2. Column 2 serum albumin with a low pI (4.7) was observed to have the highest movement in the gel due to its high attraction to the positive charge in the electrophoresis. Column 3 shows the lowest movement due to…

overexpress many tumor-specific receptors, which can be used as targets to deliver cytotoxic agents into tumors[63]. Various ligands or active targeting agents used are antibodies, growth factors (vascular endothelial growth factor), receptors (such as transferrin, epidermal growth factor receptor), ligands (including peptides and small synthetic organic molecules), nutrient…

they identified GLUT4 that was both in large and small depos. This then represents GLUT4 specific pre-endosomal storage compartments and recycling endosomal compartments. The small depos were then subdivided into transferrin receptor-positive depots recruited by contractions and transferrin receptor-negative depots recruited by insulin. They saw that co-localization of CD36 and GLUT4 was not observed and thus concluded that GLUT4 specific pre-endosomal storage as an intracellular depot of CD36…

proper accommodation of lens (Janssen et al. 2012). Previous studies reports , CB synthesizes and expresses multiple neuro endocrine proteins such as different as neurotensin, natriuretic peptides,and somatostatin, steroid-converting enzymes, transferrin, transthyretin,angiotensin, and growth factors(Coca-Prados and Escribano 2007) these endocrine molecules play role in regulating IOP, the composition of the aqueous humor. The ocular microenvironment of blood-aqueous barrier is…

β-barrel arrangement in which large loops link together β-strands. These strands make up a majority of the capsid and create protruding loop structures that inhibit antibodies from binding and define the virus’s host range by binding to host specific transferrin receptor proteins…