Tiotropium

Spiriva HandiHaler There are many types of inhalation equipment and devices on the market. I decided to research and compare the Spiriva Handihaler with the other bronchodilators. To find out why it was chosen for a resident where I work, who has C.O.P.D. I want to develop a broader understanding of the medication. It is important to be aware of the benefits or disadvantages of the medications that I dispense, in order for me to be thorough, and efficient in my job duties. Spiriva HandiHaler Spiriva HandiHaler (tiotropium bromide inhalation powder) has been modified to include the generic and brand name. It is manufactured by Boehringer-Ingleheim (1). The Spiriva HandiHaler consist of the inhalation device and the capsule. The Spiriva capsules are a light green, gelatin capsule. The capsules are filled with a dry powder containing the medication called Tiotropium bromide. The capsules are only to be used with the HandiHaler for oral inhalation, and never to be swallowed. The amount of the drug delivered to the lungs varies with each individual as to how strong they can inhale the medication. Another factor about how much drug is delivered due to exposure…

in the cardiac tissue and smooth muscle, and M3 receptors are in smooth muscle and secretion glands (Alagha, 2014). The M1, M2 and M3 receptors, are located throughout the bronchial tree. By targeting these receptor sites, bronchodilation is achieved as well as a decrease in mucus production and inflammation. The FDA recently approved the use of a new muscarinic antagonist drug aclidinium bromide also known as Tudorza. It is selective for M3 muscarinic receptors and disassociates from the M2…

using both tools as a predictor of exacerbation frequency and mortality is better than using FEV1/ FVC on its own. Both guidelines also use FEV1 ratio as a guide for inhaled pharmacotherapy. Contrary to this, (NICE, 2010) and (GOLD, 2016) fail to specify a particular drug that should be used. Instead the guidelines state medication prescribed should be based on cost. This could have a negative influence on Tim as receiving treatment for management of COPD that is considered the cheapest does not…

emphysema is albuterol (i.e., Proventil,Ventolin), most commonly available as a metered-dose inhaler (MDI). It is short-acting – acts within minutes to relieve symptoms – and one dose can provide relief from 4-6 hours. If a patient with emphysema has some extent of dyspnea at rest, albuterol can be prescribed at regularly scheduled doses, either through the MDI, or by nebulization (delivery of medication via inhalation). Ipratropium bromide (i.e., Atrovent) is another bronchodilator prescribed…

bronchodilators, and renoceptor agonists (AR), muscarinic receptor antagonists and xanthenes that can be used alone or combined together. The Long Acting bronchodilators can be either LABA (long acting beta2 agonists) Brovana (arformoterol) taken twice a day or LAMAs (long acting muscarinic antagonists) like Spiriva (tiotropium) taken once daily. These medications are taken once or twice daily to keep the airways open. Side Effects Because bronchodilators are stimulant, common serious side…

history of hypertension, COPD, and Type II Diabetes Mellitus. His baseline vital signs are a temperature of 36.8 degrees Celsius, a blood pressure (BP) of 127/79, a respiratory rate of 18 while resting and 24RR while ambulating, a heart rate of 89 and an oxygen saturation rate of 93% on room air. His current random blood glucose level is 10.5 mmol/L, potassium is 3.8mmol/L, sodium is 142 mmol/L, albumin 30g/L, hemoglobin 129 g/L, creatinine is 62 umol/L and blood urea nitrogen is 4.6 mmol/L. His…

for preventative purposes. It works by opening up and relaxing the airways. Common short-acting bronchodilators: Salbutamol (Ventolin), Terbutaline sulfate (Bricanyl). b) Long-acting Bronchodilators: This medication prevents shortness of breath by relaxing the muscles in the airway to prevent a spasm from happening. This medication is often for daily use and used to prevent shortness of breath. Common long-acting bronchodilators: Salmeterol xinafoate (Serevent), Formoterol fumerate (Foradil,…

of treatment, however, both pharmaceutical and non-pharmaceutical options, that can allow a person with this disease to live a more comfortable life. Some pharmaceutical options include long-term oxygen therapy to decrease breathlessness, long-acting inhaled bronchodilators, as well as short-acting inhaled treatments which are used for sudden, unexpected onsets. Bronchodilators work by decreasing hyperinflation, relaxing smooth muscle, and decreasing resistance in the airways, which help to…

approximately 48 weeks. Hypertonic saline may also be referred to as a mucolytic agent because it helps to break down mucus. Another mucolytic agent that may benefit a CF patient is inhaled dornase alpha (Pulmozyme). Dornase alpha helps to break down the disulfide bonds of the thick bronchial mucus and it reduces the DNA polymers into shorter units after the treatment is administered.1 Bronchodilator treatment is a standard commonly used treatment in CF. Inhaled bronchodilators are routinely…