Thrombocytopenia

Thalidomide Sold under the brand name Immunoprin, among others, is an immunomodulatory medicate and the model of the thalidomide class of medications. Today, thalidomide is utilized chiefly as a treatment of specific tumors (different myeloma) and of an intricacy of sickness. Thalidomide causes birth surrenders The FDA and other administrative organizations have endorsed showcasing of the medication just with an auditable hazard assessment and alleviation methodology that guarantees that…

Advanced pancreatic carcinoma (APC) has a poor prognosis and chemotherapy remains the most common approach. Gemcitabine was the only drug recently approved for use as single agent therapy in APC. However, the combination of oxaliplatin and 5-fluorouracil (5-FU) has shown some promising results. This phase II trial was conducted to investigate the efficacy of oxaliplatin, 5-FU, and folinic acid (FOLFOX-6) in previously untreated APC patients. METHODS: We studied response rate, time to progression…

Zika virus (ZIKV) is a flavivirus transmitted through the bites of infected Aedes species of mosquitoes. In 1947, ZIKV virus was first recognized in Uganda in monkeys through a system that observed yellow fever. Later in 1952, the virus was acknowledged in humans in Uganda and the United Republic of Tanzania. Since then, there has been reports of outbreaks of ZIKV in Africa, America, Asia and the South Pacific. In 2007, the first large outbreak of ZIKV was reported from Yap Island. ZIKV is…

The pathogen is dengue virus. The main mosquito vector is Aedes. Both diseases can cause acute febrile illness. However, malaria can be chronic while dengue cannot. The specific triads of dengue, atypical lymphocytosis, hemoconcentration and thrombocytopenia might be a clue for differential diagnosis of dengue infection from other tropical infections including to…

Question 1 What are her risk factors for developing a VTE? (Identify all factors) Answer to Question 1 The risk factors that predisposes Mrs. X to develop a venous thromboembolism (VTE) are: advanced age, malignancy (cholangiocarcinoma), trauma (multiple falls), and recent major livery surgery (Schwartz & Rote, 2014, p. 1048-1050). Patients who are in their advanced ages are at risk in developing a VTE due to slower blood flow in their veins (Schwartz & Rote, 2014, p. 1048). Additionally,…

Mitochondria and caspases are essential elements of the controlling mechanism of apoptosis 1. Caspases, a family of enzymes that are key effectors of apoptosis, are cysteine proteases that cut after aspartic acid residues. Several of these enzymes, like caspase 3 and caspase 7, are responsible for many of the effects of apoptosis. These effects include cell shrinkage, PS externalization, and membrane microvesiculation 2-5. Cytochrome C, a component of the electron transport chain, is normally…

The two critical needs in treatment to treat osteosarcoma is to prevent relapse into osteosarcoma and better treatments after surgery. Current treatments in osteosarcoma involve surgery, chemotherapy and radiation therapy. However, the chances of cancer relapses are extremely high. Thus, we need more efficient post-surgery treatments to prevent relapsing of a much stronger cancer. Several new drugs for chemotherapy are being tested to provide better results but none of the drug alone has shown…

(ages 8 to 42 days) were generally supportive of the clinical benefit that was seen in the ENDEAR trial. Treatment with nusinersen may lead to respiratory tract infections and constipation and the prescribing label notes an increased risk for thrombocytopenia, coagulation abnormalities and renal toxicity despite that it is the first drug approved to treat pediatric and adult patients with…

reduced by 50-70% in patients with severe renal impairment. Adverse effects: Most common adverse effects of milnirone are ventricular and supraventricular arrhythmias, hypotension, headache and anginal chest pain. Although clinically significant thrombocytopenia has been observed in nearly 10% patients receiving amrinone, it is rarely seen with…

Underlying disease :(Diabetes- Hypertension- Asplenia- Immunodeficiency- Cirrhosis- Hyperlipidaemia- Alcoholism) – clinical outcome (Death- Microcephaly- Recovery) -Laboratory finding :CFS (Neu- Lymph- Pro- Glu) – Blood glucose – Leukopenia- Thrombocytopenia- Complet blood count(WBCs-RBCs-PL)- ESR- CRP- Blood culture- CSF culture- PCR- Liver function- Renal function- Electrolyte(Sodium- Potassium) – Bicarbonate- DIC- Interferon-gamma- Tumor necrosis factor alfa- Interleukin 6- Interleukin 8-…