The Signal-Man

INTRODUCTION Ca2+ as an intracellular second messenger is indispensable for the physiology of organisms and the molecular regulation of cells. The cytosolic free Ca2+ concentration is a crucial signal for a variety of neuronal processes including neurotransmitter release, control of membrane excitability, synaptic plasticity, and cognition. Ca2+ homeostasis in neurons is accurate controlled by several types of Ca2+ channels or the activity of Ca2+ transporters with either locate on the plasma…

Inverse agonism has great potential as a possible therapeutic treatment option in the future” Inverse agonism: Inverse agonism is phenomenon associated with G-protein coupled receptor (GPCR), in which inverse agonist binds to the same receptor as an agonist but induces an opposite pharmacological response to the agonist. For inverse agonist response the receptor must have an intrinsic activity in the absence of any ligand1,2. How inverse agonist act? According to the two state receptor theory,…

1.7 III (b) VEGF: VEGF is also known as vascular permeability factor (VPF) is an endothelial cell specific mitogen in in vitro and is the main factor responsible for vasculogenesis and angiogenesis in a variety of in vivo models. The gene transcripts level of VEGF is stimulated at the time of implantation because process of implantation occurs under hypoxic condition. In rodents, VEGF is involved during embryo–endometrium crosstalk by regulating endothelial cell proliferation and vascular…

The True Portrayal of Alcoholism Sherman Alexie written a novel about a boy’s journey as a Native American living on a reservation in the book, The Absolutely True Diary of a Part-Time Indian. One may think the addiction may not be as prominent in there society due to how Native Americans are usually perceived, such as free, family oriented, and caring spirit. However, Sherman Alexie tells a more in depth relationship that Native Americans and Alcohol share. Sherman Alexie did receive some bad…

In Sherman Alexie's novel The Absolutely True Diary of a Part-Time Indian Junior must balance his acceptance and rejection of reservation culture in order to be happy. This is first shown when Junior tells his best friend Rowdy that he is switching schools, next it is shown when his tribe gives him peace after his grandmothers passing, and finally it is shown when Junior shows empathy for his tribe. Junior first rejects tribal culture when he leaves the reservation to go to Rearden. This is…

The Trials and Tribulations of a boy: The Diary of a Part-time Indian Junior, who is the main character in the Novel the Absolute diary of a Part-time Indian, is a young boy who is searching for his soul purpose in life. Growing up in poverty on a reservation, Junior knows that he must do whatever it takes to make his dreams come true. Through the experiences in his life, Arnold has learned what it is like to grow up in poverty and what difficult choices are made for these people in everyday…

In the story ‘’Superman and Me’’ Sherman Alexie portrays life on an American Indian reservation. He does this by showing the ways the classes of people are determined and even the way the people were treated and expected to live. He shares stories from his own life and his own views.The ways he shares his opinion and story shows the determination he had to change the lives of so many. The quote ‘’ I throw my weight against their locked doors. The door holds. I am smart. I am arrogant. I am lucky…

To come from poverty and break out of it is an enormous challenge. In order to conquer this limitation, one must remain hopeful. Sherman Alexie portrays Junior's struggle to remain hopeful. In The Absolutely True Diary Of A Part Time Indian,the cynical attitude that is passed down, lack of hope and inertia on the reservation turns children, like Junior, into despairing people convinced that they are going nowhere in life and there is nothing they can do about it. But Junior overcomes this by…

He has the internal struggle of trying to please his family and the values of where he came from while trying to find out who he is and what he wants to do with his life proves to be a difficult life task. But Arnold Spirit shows people the way to cope with these hardships in a novel by Sherman Alexie. The Absolutely True Diary of a Part-Time Indian is a novel about Arnold Spirit, the main character that lives on the Wellpinit Reservation with his family. Arnold struggles with finding his…

Role of Basketball in Part-time Indian The Absolutely True Diary of a Part-Time Indian, written by Sherman Alexie, is about a young Indian boy, Junior, and his struggle to find his place in the reservation and the white community. Basketball is an essential theme in the story that connects both of Junior’s worlds. Though basketball, Junior gains confidence and perseverance, insight into different ideas and worlds, and realization that status doesn’t determine your future. Junior learns…