Telomerase

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    According to the seventh edition pathophysiology text, "Pathophysiology is one of the most important bridging sciences between preclinical and clinical courses for students in the health sciences and it requires in-depth study at an early stage in the curriculum.” (McCance and Huether 2014) To understand pathophysiology is crucial in medicine and for those entering health science related careers. As McCance and Huether explain, Pathophysiology opens many doors for numerous people, illnesses, and…

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    Highlands Ranch, CO, June 22, 2012 Dr. Chad Prusmack, through his nutraceutical company PruTectRx, has been authorized by T.A. Sciences to prescribe the telomerase activator, TA-65. Popularized by Suzanne Somers in her book, Bombshell: Explosive Medical Secrets that Will Redefine Aging, TA-65 has been shown to lengthen telomeres in DNA strands, which can help slow aging, hinder the development of cancer and decrease genomic instability. TA-65 is only available through authorized,…

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    Telomeres In Aging Summary

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    Cells divide more often as they become cancerous, causing telomeres to become very short. In that case, telomerase enzymes may be made by the cell to escape death. These enzymes prevent the telomeres from getting even shorter. If scientists could learn how to block telomerase, they could potentially stop cancer. This however would involve them to have an understanding of exactly how aging of cells work and directly how it correlates to the…

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    Systemic Telomere

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    and reorganization. Telomere length is the result of the equilibrium between shortening and lengthening mechanisms, and in many different organisms there is a decrease in lenght with increasing age. This suggests that the activity of the enzyme telomerase (which is a specialized reverse transcriptaze) is limiting, even in stem cell compartments. Telomere and aging Aging is usually defined as the progressive functional loss of tissue function that eventually leads to death. This can stem from…

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    Telomeres

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    Telomerase, due to its TERT sub unit, is an enzyme that has a reverse transcriptase function (Autexier and Lue, 2006). The TTAGGG repeat sequences can be added to each telomere structure since it can use a short RNA strand as a template to synthesise telomeric…

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    Melanoma Case Studies

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    is believed to cause POT1 mutation carriers to have longer telomeres, probably through the abolition of the ability of shelterin to protect the telomeric ssDNA repeats, allowing access by components of the DNA damage response pathway and/or the telomerase complex. One study described a founder mutation (p.S270N) in POT1 in Italian melanoma families, with mutation carriers having longer telomeres than non-carriers. In the absence of shelterin , telomeres resemble unstable genomic DNA, known as…

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    Marching Band Essay

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    creating a tumor which hijacks your own bodily functions to allow it to survive even longer. In class I also learned about how cancer cells can produce telomerase in order to stay alive by adding longer telomeres to the end of chromosomes so there is more protection to the DNA. During class I was thinking that if scientists could somehow replicate telomerase and release it to the public as some sort of pharmaceutical, then theoretically it would be possible to be immortal. In this camp I…

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    Eukaryotic Chromosomes

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    as end-to-end fusions, and degradation (Martens, et al. 2016; Nielsen, et al. 2015; Savela, et al. 2013). Telomeres are not infinite, but they can be regenerated by the enzyme telomerase. Telomerase is active in utero, as well as in some diseased cell types like cancer cells; however, in healthy somatic cells, telomerase is present either in very low levels or is not present at all (Nielsen, et al. 2015). As organisms age and their cells undergo more rounds of replication, their telomeres…

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    Chronological lifespan of S. cerevisiae mutants lacking telomere capping protein Cdc13 and Exo1 Lay summary For over 25 years, yeast has been used as a model to understand cellular processes such as how; DNA is repaired and produced, also for understanding different aspects of the cell lifecycle and principle molecular processes in eukaryotes (the same type of cells that make up humans, animals and plants). Because yeast can be easily grown until it dies in a relatively short time, it is an…

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    Soda is an addiction and all addictions have corruptive side-effects. Some side-effects of soda include irritability, restlessness, tension, insomnia, high blood pressure, gastrointestinal disturbance, excessive urination, irregular heartbeat, cell damage, dehydration, an impaired digestive system, liver problems, metabolic syndrome, accelerated aging, and cancer. Soda has toxic chemicals-brominated vegetable oil, or BVO, is an example. BVO is an industrial chemical used as a flame retardant in…

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