Suppressor

increased lysosomal damage and cytotoxicity of thiosemicarbazones towards P-gp expressing tumor cells.[28] 3.3 Inhibition of Metastasis :Metastasis accounts for the maximum deaths due to cancer. NDRG1 (N-Myc downstream regulated gene 1) is a metastasis suppressor protein [30,31]. It inhibits primary tumor growth, angiogenesis, and metastasis [32-34]. Thiosemicarbazones were found to upregulate the NDRG1 protien by depleting the iron from tumor cells resulting in a state of hypoxia. [35,36] This…

Elucidating the role of Heat shock proteins in poly glutamine (Poly Q) model in Dictyostelium discoideum . Introduction : Expansion of CAG trinucleotide repeats encoding poly glutamine (poly Q) tract in other wise unrelated proteins are responsible to atleast nine diseases . These diseases include Huntington’s disease (HD), spinobulbar muscular atrophy, dentatorubral pallidoluysian atrophy, and spinocerebellar ataxia (SCA) types 1, 2, 3, 6, 7, and 17.(1) Clinical features include ataxia and…

For adolescents the most common treatment is hormone suppressors. Their job is to stunt development of natural secondary sex characteristics. To achieve the characteristics of the desired gender people may take cross-sex hormones, this means natal females begin taking testosterone and natal males take estrogen…

In the world today cancer is a frequently conferred issue. From treating cancer, to curing it, to preventing it. Most people understand the basics of cancer but do not know anything about the molecular genetic side of it. Although there are many reasons for someone to develop cancer that is not linked to genetics, there are many reasons that are linked to genetics. Among woman in the United States ovarian caner is the fifth leading cause of cancer related deaths ("BRCA1 & BRCA2 "). “Ovarian…

I used to dread the walk down the hallway to the 1st grade classroom due to hearing the derogatory marks aimed at me. My crime was being different. I spoke Punjabi instead of English because it gave me comfort that no one else attempted to give. I wore my clothes differently out of respect for my religion and ate my culture’s food. I kept my head down whenever they told me to go back from where I came and suffered due to my differences. To avoid the abuse, I yearned to be like them. I started…

ESKAPE pathogens are six organisms that bring a huge threat to human, because they are drug-resistance. Scientists have not found antibiotics that are effective since the pathogens are multi-drug resistance. Multi-drug resistance is top three on global public health that are mostly caused by nosocomial infections (hospital-acquired infection caused by bacteria, fungal and viral, parasites and other pathogens). The six pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella…

exploited marriage. Through the protagonists’ journey to self-realization, both Gilman and Ibsen use their literary works to draw parallels to an oppressing society and a hunt for freedom and individuality by showing both women overcome over their suppressors. During the 19th century, women were considered inferiors when compared to the opposing gender. In each of the literary works, both Jane and Nora suffered from a suppressing society that was embodied by their husbands. This is evident…

Most people think mutation is a bad thing, but it can be beneficial to human because it creates genetic variations and survival advantage. Mutation is a process that changes the DNA sequence. It has been studies that multiple genes are the possible risk factors for breast cancer. However, mutation of the genes relates to breast cancer because it is a result of critical genes growing and dividing uncontrollably, which are responsible for cell growth and repair damaged. According to Genetic…

Introduction Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the key enzyme for carbon fixation and four different holoenzyme form of Rubisco are found in different organisms (Tabita et al., 1999; Tabita et al., 2007). Most abundant Rubisco forms 1 consist of eight large subunits and eight small subunits are found in algae, cyanobacteria and higher plants (Shively et al., 1973). The multiple nuclear gene encoding small subunits of Rubisco is called rbcS. rbcS exists only in Rubisco…

spreading the word. In 312 c.e., the Roman Emperor Constantine converted to Christianity, shortly thereafter declaring it the official religion of the Roman Empire. This act gave the religion a sense of legitimacy, they went from suppressed, to suppressor. A core tenant in…