Superoxide dismutase

I-Kappa-B-alpha which is often abbreviated IkBa is a protein whose role is to mask the nuclear localization signals to inhibit the NF-kB (nuclear factor kappa beta) proteins by keeping them in inactive states and isolating them in the cytoplasm, this inhibits the NF-kB transcription factors and blocks the NF-kB transcription factors from binding with DNA. NF-kB is a protein complex that is responsible for controlling cytokine production, transcription of DNA, cell survival, and plays a key role…

important micronutrient, which functions as a co-factor for antioxidant enzymes such as Glutathione peroxidases, one of the most powerful antioxidants in the body. Copper is a cofactor for many vital enzymes, including cytochrome c-oxidase and superoxide dismutase (other minerals function as co-factors for this enzyme are manganese and zinc). Zinc is a co-factor for many enzymes that regulate growth and development, gonadal function, digestion, and DNA (nucleic acid)…

INTRODUCTION Tomato (Solanum lycopersicum L.) and Potato (Solanum tuberosum, L.) are the most economically important vegetable crops in Egypt and the most widely grown vegetables in the world. The disturbance of its production affects severely it's local and export impact, because it is considered a very important consumption crop with high nutritional value and a potential export crop for the Egyptian farmers. In Egypt about 20% of total area devoted for vegetable production is cultivated…

Commonly referred to as Lou Gehrig’s disease, Amyotropic Lateral Sclerosis is a neurodegenerative disease where the motor neurons in the brain and spinal cord die (Harmon, 2012). Diagnosis generally occurs after age fifty and from that point, the patient generally has three to five years until his/her motor neurons controlling the diaphragm die, resulting in death by asphyxiation (Al-Chalabi et al., 2014; “Amyotrophic Lateral Sclerosis,” n.d.). An anomaly to this generalization is Stephen…

percentage; there is only a fifty percent chance that each offspring has to develop Familial ALS in their lifetime. Around twenty percent of these cases that people are diagnosed with have a mutation in their gene that codes for the protein Cu/Zn superoxide dismutase. This gene is known for being located on chromosome twenty one. People that are diagnosed with Familial ALS are known for having sensory loss, but that is the only difference found between Familial and Sporadic on a neurological…

General Introduction Dietary lipids: Dietary lipids consist of a broad group of compounds that are soluble in organic solvents and insoluble in water. Their density is lower than water and consistency varies from liquids to solids at normal room temperature, depending on their structure and function. They are also referred as ‘Oils’ which are liquid and ‘fats’ which are solid at room temperature. Lipids are the important constituents of diet due to their higher energy value. One gram of lipid…

[20]. However, Berkis et al.,2005 had reported that null genotype is protective gene regarding the risk of T1D[6].The difference from our study can be explained by several possible mechanisms; up-regulation of other antioxidant genes like superoxide dismutase gene that follows the depletion of GST activity., meaning while, these explanation possibilities needed to be confirmed in further research. Previous studies reported that GST T1 or M1 gene polymorphisms are regarded as a risk factor for…

We first evaluated whether Honokiol treatment was toxic to the APP-CHO cell line. Cells were treated with various concentrations of Honokiol (0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM and 20 μM) for 24 h and cell survival was determined by Prestoblue® assay (Fig.1A). As shown in Fig.1A, when exposed to Honokiol concentrations of 10 μM or lower, the viability of APP-CHO cells was the same as untreated control cells. However, a significant decrease in cell viability was observed with 20 μM Honokiol…

Science is part of an everyday life. The field of genetics can impact someone’s health, political view, faith, and job. Every day, society is expanding the applications of such potentials to cure genetic disorders, modify organisms, and identifying criminals. Every year, there are over eight million children born with a serious disorder that is caused by genes. “The most common genetic defects include heart disorders, Down syndrome and incorrectly formed backbones and brains. They also include…

To study the tolerability of the analgesic autoinjector in the non-rodents( rabbit) by analysing biochemical parameters. 8.1 Introduction The objective of drug discovery and drug delivery system is to treat infections and particularly pain and suffering during the ailments and thereby maintaining a healthy human population. Any development in medical field is evaluated using a variety of clinical procedures prior introducing to humans. In pharmacological research, animal usage has become a…