Steatosis

(2004) and Kleiner et al. (2005) assed multiple independent features for the diagnosis of steatohepatitis and did not just based their findings on a single histological feature. The lesion due to accumulation of fat in the form of triglycerides within hepatocytes is termed as steatosis and the minimum criteria for diagnosing NAFLD the presence of > 5% steatotic hepatocytes in a liver tissue section (Brunt and Tiniakos, 2010). On the other hand, the minimal criteria for the histological diagnosis of adult NASH includes steatosis, hepatocyte injury, usually in the form of ballooning, and lobular inflammation, typically localized in acinar zone 3 while fibrosis is not a required diagnostic feature of NASH (Brunt and Tiniakos, 2010). According to Brunt and Tiniakos (2010), hepatocellular injury in NASH can take the form of ballooning, apoptosis, or lytic necrosis. Brunt and Tiniakos (2010) reported that ballooned hepatocytes can be observed as enlarged, swollen, rarefied, pale cytoplasm and, show a hyperchromatic nucleus, usually with a prominent nucleolus. Apoptotic bodies are acidophilic and lobular inflammation is usually mild which consists…

Biopsy proof was not obtained. Statistical analysis The optimal threshold for diagnosis of hepatic steatosis on contrast-enhanced CT was determined by Receiver Operator Characteristic (ROC) curve and calculated sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy over a range of possible liver attenuation diagnostic threshold, L-S attenuation diagnostic threshold or combined. The maximal overall accuracy value was chosen. Presence of focal fat…

viruses precisely Hepatitis B or C viruses. HBV is spread through contact with body fluids like saliva, urine, semen, vaginal secretions and plasma whereas HCV is spread through contact with blood and blood products. Patients infected with HBV usually recover completely and less will develop chronic hepatitis but patients with HCV usually develop chronic hepatitis. Chronic hepatitis may cause liver cirrhosis and eventually liver cancer. Heavy alcohol use also contribute to hepatocellular…

et al., 2016). The diagnosis of NAFLD involves the exclusion of alcohol drunkard and other aetiologies causes of liver diseases (Lytle and Jump, 2016). NAFLD can be diagnosed by imaging the abdominal ultrasound, which is appearing the most commonly used forms (De Moura Almeida et al., 2008). Furthermore, liver biopsy is the gold standard to diagnose fatty liver diseases (Chalasani et al., 2017). In fact, fatty liver disease is an incidental finding in the evaluation of individuals with severe…

would be out of balance and those vitamins literally go down the drain. 4. Gut Health In some animal fats, there is an acid called butyrate. Butyrate helps the cells in the lower GI system, specifically the colon, healthy. Without it, they cells will die, but with it, it protects the cells from self-destruction and aids in the production of probiotics. Additionally, the butyrate can play a part in protecting against colon cancer. 5. Liver Health Fatty liver syndrome can occur when there is…

High blood pressure is when the force of the blood is too high against the wall of the arteries. Arrhythmias can also cause high blood pressure since the irregularity of the heart beat can change the amount of blood being pumped to the organs. The liver is one of the major organs in the body that detoxifies chemicals, metabolizes drugs and produces bile that line the intestines. Alcoholism can cause many problems to the liver such as inflammation, steatosis, alcoholic hepatitis, fibrosis, and…

iron-containing siderophores. In mammalian liver, LCN2 protects against inflammation, infection, injury and other forms of cellular stress. Because previous work indicated that LCN2 is a key modulator of hepatic fat metabolism and homeostasis, we performed a comparative profiling of the proteins and lipids of wild type (WT) and Lcn2-deficient mice fed either standard chow or a methionine- and choline-deficient (MCD) diet. Label-free proteomics and 2D-DIGE protein expression profiling identified…

kidney function to fully recover from the hydrodynamic stress (Table 1). No statistically significant differences were detected in the creatinine levels of the hydrodynamically injected mice and the non-treated control mice at the analyzed time points. No statistically significant differences were found in the mean ALAT values of gene transfer receiving mice and the non-transfected control either. Generally, the plasma ALAT levels of the mice increased gradually throughout the study. However, as…

The Leptin receptor, Ob-R, is a member of the class-1 cytokine 25 receptor family and was originally demonstrated in hypothalamic neurons. In animal studies, the main role of leptin seems to be prevention of lipid accumulation in non-adipose sites, such as the myocardium, skeletal muscle, pancreas, and liver. Initially leptin was characterized as a regulator of body weight and energy expenditure. In NASH patients serum leptin levels are increased compared with gender and BMI matched controls.…

‘Love Your Liver’ is a worthwhile initiative for All Saints Catholic Girls College. The ‘Love Your Liver’ program should be introduced into All Saints Catholic Girls College’s list of yearly events due to many reasons. This program creates a healthy eating habit to aid a healthy lifestyle, promotes the importance of a healthy liver, and keeps your skin, nails and hair in good condition. ‘Love Your Liver’ is a worthwhile initiative for All Saints Catholic Girls College and should definitely be…