Statin

Statins represent a class of cholesterol-lowering agents used for the treatment of dyslipidemia (abnormal amount of lipids) and the reduction of atherosclerotic cardiovascular disease risk. Their broad and potent effects on the lipid profile and cholesterol-independent pleiotropic cardioprotective effects positioned them among the most prescribed medications worldwide. Statins were introduced in the late 1980s and early 1990s as a novel group of cholesterol-lowering drugs in attempt to offer patients with hypercholesterolemia a safe and effective means of reducing their plasma cholesterol. Research has shown that they not only have an important effect in reducing blood lipid levels, but also an individual’s risk of vascular disease in general. Chemical structure and pharmacokinetics The chemical structure of statins is constituted by two…

mellitus among statin users: A disproportionality analysis using FAERS data Authors: Ajinkya Pawar, BS1 1College of Pharmacy, University of Rhode Island, Kingston, RI Objective: To evaluate diabetes mellitus adverse events reported for the statin use. ¬ Background : Statins, a class of medications prescribed to reduce blood levels of LDL cholesterol, have been found to increase the risk of developing diabetes mellitus (DM).1 Such association has been observed in multiple observational studies,…

However, they are also of interest in cancer as they have been shown to affect its many aspects (Pich et al., 2013). The mechanism that underpins the effectiveness of statins for hypercholesterolemia is the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that catalyses the formation of mevalonic acid from HMG-CoA. Mevalonic acid is a precursor of cholesterol, and therefore inhibiting HMG-CoA reductase is very effective for inhibiting cholesterol synthesis.…

fifty five percent. They say statin drugs are supposed to reduce the risk of stroke and cholesterol, but they actually increase the risk of dementia. The way that people live now is causing research to say that we will continue to die from Alzheimer’s. Two major contributors to alzheimer’s are people that are obsessed with low fat diets and statin drugs. Just now researchers are discovering that statin drugs cause deficiencies in the “Alzheimer’s brain”. The brain includes fat and cholesterol…

A study completed during the influenza seasons of 2009-2011 investigated the relationship between long-term statin therapy and its influence on influenza vaccine efficacy (VE). The results of this post hoc analysis of a cross-sectional observational study, along with a clinical trial, indicated that statins caused a decreased antibody titer after vaccine administration. Over 6000 adults over the age of 65 that had been on statin therapy for at least 28 days before influenza vaccine…

This peer-reviewed review article seeks to assess coenzyme Q10 (CoQ10) serum levels in patients taking statin medications. It also determines whether CoQ10 supplementations are beneficial for alleviating or improving statin-related myopathic symptoms. These improvements can be inferred by symptom improvements as well as increases in plasma levels of CoQ10. In this study, an electronic search is conducted on several databases to select studies performed within 2005-2010. The references of the…

regarding the possibility of statins causing memory loss, the following are the information I came across. According to Clinical Pharmacology, rare cases of cognitive impairment (memory loss, forgetfulness, memory impairment) have been associated with the use of statins. On Facts & Comparisons, it states that cognitive impairment is a rare adverse effect of rosuvastatin, pravastatin, and lovastatin. Additionally, according to LexiComp, cognitive impairment, such as memory loss and memory…

Background: Atrial fibrillation (AF) is the most common coronary artery bypass graft (CABG) post-op arrhythmia. This complication can increase the patient’s chances for a longer hospital stay, stroke, or death; resulting in additional healthcare costs. Prescribing statins (3-hydroxy-3-methylglutaryl COA reductase inhibitors) to reduce the risk of postoperative AF (POAF) is well studied, as they provide anti-inflammatory and antioxidant benefits within hours of initiation. However, whether the…

The biggest consequence of consuming statins is that it increases the risks of developing diabetes. Like explained before, cholesterol is made by the liver when excessive amounts of sugars are ingested. Statins block the mechanism in which the liver transforms sugar in cholesterol (Diurez and Fruchart). This amount of sugar goes back in the blood and, after a certain time, this process can lead to diabetes (Mercola, “Do You Take Any of These 11 Dangerous Statins or Cholesterol Drugs?”). This is…

I agree to start the patient on Atorvastatin. According to American College of Cardiology (ACC) and American Heart Association (AHA) patient without diabetes, 40 to 75 years of age with an estimated 10 year ASCVD risk greater or equals to 7.5 should be started on statin therapy (Lambert, 2014). This patient had ASCVD risk of 21.3% and should have been started on moderate or high statin therapy. Atorvastatin 10mg is the moderate statin therapy. In addition, atorvastatin and simvastatin are the…