Solid-phase synthesis

after take-off that the devastating event of the day began. Summary 0.06 milliseconds after lift-off, darkish-grey puffs of smoke began discharging from the right solid-fuel rocket booster. These dark puffs of smoke were hot gases of up to 6,000 °F emanating through…

sections of this report outline the events leading up to and during the failure, analyze the reasons behind it, and identify key lessons to apply to future space travel. DESCRIPTION OF FAILURE The Shuttle Launch system consists of three components: The Solid Rocket Boosters (SRBs), the External Fuel Tank (ET) and the Orbiter. Several different types of insulating foams cover a large part of the ET, which contains the cryogenic liquid hydrogen and oxygen that fuel the three Space Shuttle Main…

Brandon is sitting at his crowded office desk with stacks of papers in the corner, and his lunch out in front of him in Wichita, Kansa, staring out the window watching the wheat as it delicately flows in with the slight breeze. Breaking news just came on tv, a hurricane is about to hit Texas and devastate thousands of people. Brandon automatically starts racking his brain on what to do. Brandon thoughts are all over the place. Should he take that long drive and go down to help, or should he…

Pharmaceutical synthesis involves various methods and techniques. These techniques are crucial and require profound knowledge and understanding of the chemistry and handling of drug compounds. A pharmaceutical drug (also referred to as a pharmaceutical, pharmaceutical preparation, pharmaceutical product, medicinal product, medicine, medication, medicament, or simply a drug) is a drug used to diagnose, cure, treat, or prevent disease.[1] Most drugs are natural: collected from sources such as…

PE2008 – Phase Equilibrium Thermodynamics Assignment Kayleigh Tobin – 114378781 Separation of Water and Pyridine by Distillation.________________________ (1) Water – H2O • Density: 1,000 kg/m³ • Boiling point: 100 °C • Molar mass: 18.01528 g/mol • Melting point: 0 °C • Formula: H2O • IUPAC ID: Water, Oxidane Water is the most abundant compound on the planet’s surface. Water exists naturally in a liquid, solid and gaseous form. The liquid phase of water is the most common. The solid phase…

Despite the practical and informative nature of the Williamson ether synthesis of 2-bromo-4-methoxy-phenoxy benzyl ether. This reaction was not conducted due to an error made in which the initial product was thrown away instead the actual second phase of this synthesis was the Williamson Ether synthesis of 4-methoxy-phenoxy benzyl ether. Figure 4. Williamson Ether Synthesis 4-methoxy-phenoxy benzyl ether ____________________________________¬___ In spite of this outcome there was still much…

conditions. The 5,6 double bond of pyrimidine nucleosides also reacts with halogens and halohydrins to give the corresponding addition products (Shabarova and Bogdanov, 1994). Selected examples of the side reactions that occur during oligonucleotide synthesis are given below. Tri-O-acetyluridine (S.1) reacts with MSNT to produce the triazolo derivative S.2 (Figure 2.1.2; Reese and Ubasawa, 1980). During deprotection with ammonium hydroxide, S.2 gives cytidine (S.3). Interestingly, during…

A novel synthesis method to prepare Si3N4 nanowires from the amorphous silicon nitride (a-Si3N4) powder synthesized by low-temperature vapor-phase reaction method was investigated. Highly crystallized α-Si3N4 nanowires were synthesized from the heat-treatment of a-Si3N4 powder under ammonia atmosphere. The surface of the nanowires was smooth and clean without any attached particles. The thickness of the nanowires was in the range ~200–300 nm with the lengths of tens of micrometers. The…

name buckybowl. The smallest buckybowl to date is coronnulene, a non-planar hydrocarbon made up of five overlapping 1, 3-cyclohexadiene rings figure 1. The synthesis of coronnulene in lab is very challenging primarily because of the stress associated with the non-plannar molecule. Dr. Sygula’s lab accidentally came across of new method of synthesis. The new approach is relatively simple and has consequently been the main source of coronnulene for the lab. From coronnulene, Dr. Sygula’s group has…

The cyano-ethoxy carbonyl protection Manoharan et al. (1999) developed 2(cyanoethoxycarbonyloxy)succinimide S.27a a stable, crystalline, and convenient reagent for the protection of pendant akylamines in oligonucleotides (Figure X.X.X). The 2-cyanoethyl (ce) group is the most common phosphate protecting group in oligonucleotides; however, ce and corresponding 2-(cyanoethoxycarbonyl) group were not utilized for the nucleobase protection until 2000. Merk et al. (2000) developed…