Solid-phase synthesis

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  • Solid Phase Synthesis Essay

    A novel solid-phase synthesis methodology of N-substituted-2-aminothiazolo[4,5-b]pyrazine derivatives was developed. The key step in this synthesis strategy is tandem reaction of isothiocyanate terminated resin 2 with o-halo-2-aminopyrazine, affording cyclized 2-aminothiazolo[4,5-b]pyrazine resin 4. To increase the diversity of our library, Suzuki coupling reaction was performed at the position C6. Further functionalization of 2-aminothiazolo[4,5-b]pyrazine core skeleton with various electrophiles such as alkyl halides, acyl chlorides, and sulfonyl chlorides and cleavage from the resin with TFA in DCM generated N-alkyl-, N-acyl-, and N-sulfonyl-2-aminothiazolo[4,5-b]pyrazine derivatives. This synthetic strategy can efficiently provide a library…

    Words: 877 - Pages: 4
  • Docetaxel Solubility

    the highest drug solubilization capacity for docetaxel. Whereas, Captex and Gelucire 44/14 shown the least solubility of docetaxel in them. Based on the solubility results, Capmul PG8 NF was selected as the oil phase, Cremophore EL as surfactant and Transcutol-P as co-surfactant. Capmul PG 8 NF (HLB 6) has partial aqueous solubility over Capmul MCM C8 which may help in easy dispersion of drug in an aqueous medium [34,35]. A good combination of surfactants with low and high hydrophilic lipophilic…

    Words: 1368 - Pages: 6
  • Tuckman's Four Stages Of Group Analysis

    Tuckman has four phases of group development. The first being forming, the second being storming, the third being norming, and lastly the fourth being performing. Each of these four phases are influenced by different aspects of your group coming together and working. Essentially the three of these phases are meant to lead you to the fourth phase with success. My group has gone through all four of these phases throughout this semester, while working on our project for COM 240. Tuckman’s first…

    Words: 1117 - Pages: 4
  • The Real World In Annie Dillard's An American Childhood

    and turbulent. Adolescents go through significant phases in their journey of figuring out who they are and how they fit into the fabric of everyday life. The first one being the naive phase; this is where we believe we know everything there is to know. This is the stagnant phase where we cannot see change and think about forever in the most literal sense. Second is the turbulent phase; where we find ourselves rebelling to anything that we feel is oppressive. Lastly is the phase of awakening, in…

    Words: 854 - Pages: 4
  • Guided Discovery Approach Case Study Essay

    to ask questions of their own, and in turn allows the educator to support the child’s investigation with prompting questions to encourage critical thinking and reasoning (Campbell, Jobling and Howitt, 2015, p. 72). The interactive approach is shown below in (Appendix 2, p. 13) when the educator said “When the ball got stuck it’s because there was not enough force to propel it forward, do you know what this motion is called?” and this approach is shown throughout (appendix 2, pp. 12-17). Thirdly,…

    Words: 1669 - Pages: 7
  • Solubility Of Sulpiride In Me Components

    The area of the formed ME of each system is calculated relative to the whole area of the pseudo-ternary phase diagrams using AutoCAD program 2014. Figures 1 and 2 showed pseudo-ternary phase diagrams of various oils from different origin and fatty acid chain length such as vegetable oil (Avocado oil), long chain triglyceride (Labrafil isostearique) and GMO. These oils were tested for their effects on the area of ME formed. It was observed that the vegetable oil “Avocado” based systems gave no…

    Words: 1231 - Pages: 5
  • Nucleoside's Susceptibility To Depurination

    α-phenylcinnamoyl, naphthaloyl, 3-methoxy-4-phenoxybenzoyl, 9-fluorenylmethoxycarbonyl (FMOC), and tert-butylphenoxyacetyl (t-PAC) groups (Figure 2.1.7) provides greater resistance to depurination than with N6-benzoyl (reviewed in Beaucage and Iyer, 1992). It is believed that in the case of acyl-protected purine nucleosides under acidic conditions, the initial site of protonation is N7, rendering the protonated species more prone to glycosidic cleavage. Naturally, caution should be exercised in…

    Words: 1764 - Pages: 8
  • The Melting Point Of Urea And Trans-Cinnamic Acids

    The melting point of a substance is best described as the temperature at which a solid becomes a liquid (Bruice 2014). On the molecular level, when a compound melts the forces between the molecules become weaker. This is because when a substances heats up the kinetic energy between the molecules increase causing the molecules to vibrate. When the vibrations become strong enough for the molecules to move around and pass other molecules, the compound that is being heated up starts to melt and…

    Words: 756 - Pages: 4
  • Fepo4 Temperature

    lower than 980K and α-phase plays a dominant role over β-phase at high temperature. For the α-phase FePO4, the cell parameters increase with a non-linear trend when temperature increases linearly. The volume of the cell expands with a thermal expansion coefficient of α (K-1 )=2.924x10-5 +2.92x10-10 (T-300)2 . The reasons for the cell expansion are the cell angular variations and tilt angles, which were caused by the variations in Fe-O-P bridging angles as they are not symmetrical. The δ…

    Words: 718 - Pages: 3
  • Double Salt Lab Report

    the salt, it dissolved relatively quickly with the help of a glass stirring rod. As they dissolved the solution, it turned to a clear light blue color similar to that of the sky. The hydrochloric acid did not visibly change the appearance of the solution. Once stirred, they, lit the Bunsen burner and heated the solution until it was almost boiling, all with the stirring rod still inside the beaker. Then experimenters added 15 mL BaCl2 into the 250-mL beaker all at once, at which point the…

    Words: 1556 - Pages: 7
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