Receptors are protein molecules that receive chemical signals in the form of ligands and induce responses at cellular level. They are localized at the cell surface, cytoplasm or the nucleus, depending on their amino acid sequences. In addition to using these three different localizations to categorize receptors, the types of action of receptors are also used as a mean of classification. The four main classifications of receptors are: 1. Ionotropic (or ligand-gated ion channel) receptors, 2.…
(1-AR) are systematic vasoconstrictors: their activation constricts blood vessels by the contraction of vascular smooth muscle. These transmembrane receptors are activated by the binding of epinephrine or norepinephrine, which creates intracellular signals via activation of the G-protein. The G-protein itself is a heterotrimer; it consists of alpha, beta, and gamma subunits (Figure 1). The alpha subunit of the G-protein is capable of binding to guanosine diphosphate (GDP) or guanosine…
Grey. The walls of the Tower were all a very monotonous, dull grey. The particular wall I was staring at had a class symbol on it, albeit not attuning to my own. The symbols were mentally etched into every class, so having them painted on the walls of our home reminded us of the pride we carry. But as of late, I can’t say there has been much self-pride for me to bathe in. Being the Tower’s recon scout meant that I was assigned all the mundane chores while my other fellow Guardians got to…
In class this past week, we did an activity called the Signals Game, which I had actually done once before in high school. When I did it the first time, I was part of culture B, and I remember that I felt like such an outsider, even though there were other people that were in my culture with me. But this time, when we did it in class, I was part of culture A. For some reason, I found I was much more comfortable being in the group that tried to welcome the others than I was actually being part of…
Smoke Signals is unique among movies, in that it is the first feature film to be written, directed, co-produced, and starring Native American Indians. Most viewers of the film can easily pick up on how comfortable the creators are with its setting and its characters. We can sense that this was done by people who genuinely care about the Native American people at large. The film opens with a flashback to a Native American reservation in Idaho. In the scene the viewer watches as an infant,…
Intelligence), which consists of photography or snapshots taken by satellites or reconnaissance planes; MASINT (Measurement and Signature Intelligence), which tracks emissions or “signatures” issued by weapons such as missiles or nuclear warheads; SIGINT (Signals Intelligence), information derived from intercepted electronic communications such as phones, personal computers or radar; HUMINT (Human Intelligence or Espionage)—which is sometimes viewed as the world’s “second oldest profession”…
In the book “the Signal and the noise”, author Nate Silver talks about prediction from many different angles. Silver explains how prediction is a part of our everyday life and how it affects us. From math to history, inside of a class room or on a court/field, prediction is something we deal with on a day to day basis unconsciously. Silver talks about the benefits of failure and how failure is helpful in the long run with making predictions. Throughout the years we have made progress with…
Hypothalamic programming of systemic ageing involving IKK-b, NF-kB and GnRH (Zhang et al., 2013). Cellular senescence is when a cell’s replicative mechanism becomes arrested. This was phenomenon was first described in Hayflick’s experiment. Cellular senescence is usually due to protect the cell from becoming cancerous but it also plays a prominent role in aging (van Deursen, 2014). While senescence describes a halt in proliferation, cancer development is the uncontrolled proliferation of…
I can list all the fact in the world based on why tattoos in the workplace are and are not accepted in the workplace, but that’s not what intrigued me into writing about tattoos. I find tattoos self portraying because not only does oneself reveal based on the art made in our bodies, but the significance it has on us and the image itself. Many people may not care or know but we all have a right to express ourselves which includes showing your tattoos. Although tattoos in the workplace are not…
disorder were stopped, then serious crimes would therefore not occur.” If the smaller crimes were stopped, it would prevent bigger crimes in the future is how I see it. The simple definition is that if a broken window, left unattended, this would signal that no one cared and therefore ultimately lead to more disorder and even crime. So how did they theory begin in the first place. Well Kelling found that adding a larger amount of foot patrols in the city improved the relationship between police…