Signal

Using infliximab to treat Crohn’s disease Introduction Crohn’s disease is a type of IBD that causes inflammation in any part gastrointestinal tract from the mouth to the anus. In response to this inflammation, the body’s immune system attacks the GI tract (Dessein, 2008). The progression of this chronic inflammatory disease is brought about by the action of several cellular processes and pro-inflammatory mediators (Poggioli, 2007). Because there is no single factor that can be targeted to…

Gangs are nothing new. At the turn of the century (the early 1900s), many large police departments on the east coast had gang units to monitor the immigrant gangs who got together to protect their neighborhoods and to gather for social reasons. Gangs as most people think of them today were probably first recognized by the public with the inception of the Los Angeles gangs in the early seventies. Why do kids join gangs? The stereotype that comes to many people’s minds is that kids who join…

Charbill Klayme 0993551 Dr. Hye-Jeong Yeo Functions of SREBPs Abstract SREBPs are 1,150 Amino Acid long proteins that are used to activate cholesterolgenesis. SREBP-1a are used to induce all the response genes. The SREBP-2 are used to allow expression of the LDL receptor. Ubiquination, usually by the kinase GSK3, can be the weapon to destructing SREBPs. SREBP-1a will build more cholesterol and fatty acids in rats and mice when it is over expressed. The SREBP-1c are best studied in the…

4. Plasminogen Activator Inhibitor-1 (PAI-1) PAI-1 is used to evaluate the risk of thrombosis. It is a serine protease inhibitor (serpin), therefore it is also known as serpin E1. Human SERPINE1 gene encodes for PAI-1. PAI-1 inhibits Fibrinolysis through the inhibition of the serine proteases, Tissue plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which activate plasminogen. So any increase in PAI-1 decreases fibrinolysis consequently increasing the risk of…

In my Opinion Sherman Alexie wrote “The Joy of Reading and Writing: Superman and Me” with the purpose of informing the reader of the challenges he faced as a young Indian boy that “The Joy of Reading and Writing: Superman and Me” by Sherman Alexie was not supposed to be educated by societies standards. Alexie used his own personal experiences as a young smart Indian to express his point of view. His love of books derived from his love and adoration of his father. The purpose of this essay is to…

hroughout his journey from his poor Indian reservation to a neighboring all white school. Arnold Spirit, the main character in “The Absolutely True Diary Of A Part Time Indian”. By Sherman Alexie Junior experiences on and off the reservation helped him understand to ignore all the hate, so you can focus on more important thing and follow your dreams even if other disagree. (Body #1: One of the life lesson that Junior learned through his experience was to follow your dreams even if other…

Sherman Alexie reveals insight into Gordy when he talks about Gordy’s idea about the mysteries of the world. When Gordy and Junior are in the library, where Gordy is teaching Junior how to read, Gordy starts talking about how to properly read a book. He is explaining to Junior how you have to read a book at least three times to really read it. Junior is interested in what Gordy is saying, even if he doesn’t fully understand it. Gordy says, “The world, even the smallest parts of it, is filled…

Sherman Alexie and Octavia Butler have very different backgrounds, but the only similarity they share (that we know of) is being the minority. Sherman Alexie went to Reardon High School for a better education than offered to him by the rez. He was the only Indian there besides the school mascot. Octavia Butler is one of the few African American women to write science fiction. Their stories, too, are very different from each other, but they have a few similarities. “Jesus Christ’s Half Brother…

Alexie’s story, Superman and Me was extremely powerful and motivating. The purpose of his essay was to convince and encourage readers to never stop learning, and to always read. He used his own personal struggles to deliver a message. I never knew that school life on a reservation was that unpleasant. I had the assumption that schools on reservations were far more advanced than schools off the reservation. I was also surprised when he talked about how Indian students were not expected to succeed…

Alcoholism in Reservations In Sherman Alexie’s book entitled “The Absolutely True Diary of a Part-Time Indian,” one of the many continuous themes is alcoholism. It shows how alcohol can affect everyone surrounding it, and the destruction is causes within families or personal feelings. Junior (the main character) labels his community as a generally drunk society. The book allows us to witness the tragedies Junior has encountered first hand. Within the short amount of time Junior has lived, he…