Sickle

Sickle cell disease (SCD) is a monogenic disorders (Bhanushali et al., 2014) characterized by chronic hemolytic anemia, acute vaso-occulusive crises (Platt, 2008), and the acute chest syndrome (ACS) (Lettre et al., 2008). A point mutation in the β-globin gene, the substitution of valine for glutamic acid at position 6 of the β-globin gene (Glu6Val), is the major cause of sickle cell anemia (Platt, 2008; Mtatiro et al., 2015). The mutated β-globin gene (Glu6Val) leads to the formation of sickle…

The Crescent Moon Disease: Sickle Cell Sickle cell anemia is a disease that is passed throughout families. Sickle cell affects the red blood cells, which cause the blood cells to look like a crescent moon instead of looking like a disc, like the photo included above. There are two types of Sickle cell: Sickle Cell Anemia and Sickle Cell- Hemoglobin C. Sickle Cell Anemia is the less severe one out of the two. Sickle Cell Anemia affects many racial and ethnic groups. One in four hundred…

Sickle -cell anemia is a disease that affects the shape of red blood cells and it causes them to become a sickle shape. Sickle cell anemia was first noticed around 1670, in a tribe called Krobo in Ghana, Africa. In 1910 a physician in Chicago named James Herrick was the first person to first describe it clinically (Kiple). Since then much more information has been discovered on this disease. Such as this is a disease that people inherit from their parents if both are carriers. There are many…

Title- The Genetic Disease Sickle Cell Anemia Introduction- Throughout evolutionary history, advances in molecular biology allow molecular biologist to discover new genetic diseases. Sickle cell anemia is an inherited blood disorder in which there is a single amino acid substitution, which alters the structure and function of the hemoglobin. Although one might think that this disease only affects the circulatory system it actually affects many of the body’s systems, disrupting its functional…

Sickle cell disease is a major health burden in the Indian community. It contributes to millions of deaths worldwide however it is most prevalent in tribal populations in the rural sectors of India. “Sickle cell disease or SCD is an inherited abnormality of the red blood cell characterized by chronic haemolytic anemia with numerous clinical consequences” (Ugwu 87). The shape of hemoglobin, which gives red blood cells their color is turned from an oval to a crescent shape when the sickle cell…

Sickle Cell Disease There are many different types of hereditary diseases that affect people’s lives every day. One of them being sickle cell disease. Sickle cell disease or sickle cell anemia “is the result of abnormal hemoglobin” (Bloom 3). Hemoglobin is the “oxygen-carrying molecule of the red blood cell” (Bloom 3). In sickle cell disease, the red blood cells take shape of a crescent moon, leading to lifelong health problems. Sickle cell disease is an obstacle for thousands of people’s lives…

poison to the body? Imagine going through countless blood transfusions and bone marrow transplants. Many people are blessed never to have to worry about those things their entire lives, but that life is a reality for a person with sickle cell disease. Some compare sickle cell to cancer, but they are very different. Similarly both have severe effects on the body from the diseases themselves and from the strenuous treatment procedures. Through all the hardships sufferers, have to have hope and…

Name of disease Sickle Cell Disease Location 11p15.4 – chromosome 11, on short arm of chromosome, region 1, band 5, sub-band 4 Gene/locus HBB – haemoglobin subunit beta HTML reference Stumpf, A.M. (2013). Sickle cell disease Available form: http://www.omim.org/entry/603903?search=Sickle%20Cell%20Disease&highlight=cell%20sickle%20disease Frequency More than 230 000 children with sickle cell disease are born in Africa every year, which makes about 80% of the global total. In Europe estimated…

What is Sickle Cell Disease? Sickle cell is an inherited blood disorder that affects red blood cells. People with sickle cell disease have red blood cells that contain mostly hemoglobin. Sometimes these red blood cells become sickle-shaped and have difficulty passing small blood vessels. Hemoglobin is the main substance of the red blood cells. It can help red blood cells carry oxygen from the air in our lungs to all parts of the body. Normal red blood cells are soft round and can squeeze through…

I decided to do my paper on the genetic disorder Sickle Cell Anemia because it’s a trait that runs in my family and I have 1 cousin and an aunt that have it, so since I have the opportunity to write a paper on a genetic disorder it’s a perfect time to learn more about it. Sickle Cell Anemia is a disorder that affects your red blood cells, normal red blood cells are round where sickle cell red blood cells and hard, sticky, and shaped like sickles that you use to cut wheat, when the hard pointed…