Transporter proteins comprise 5% of all human drug targets. This category encompasses the ATP-binding cassette (ABC) transporter family, ATPases, and the solute carrier (SLC) family. SLC6 is the most exploited family among all transporters (55%), with approximately 42 drugs currently approved by the US Food and Drug Administration (FDA) (Figure 4.9a)76. Currently, around 60 clinical trials are in progress for drugs that specifically target SLC6 family members, mainly for analgesia, psychiatric…
Depression should be treated with antidepressants due to various ethical reasons that help basic mental and physical health. Depression is a serious mood disorder that enables one to easily feel sad, upset, and stressed out. Since depression is common today, more people rely on different types of treatment such as medications and drugs. “The World Health Organization reports that depression is the second leading cause of disability worldwide and, by 2020, is estimated to be the leading cause of…
This is because OCD is caused by a defective Serotonin neurotransmitter. Serotonin is a neurotransmitter in the brain that controls mood, appetite, and sleep (NCBI, 2015). If one’s body does not receive enough Serotonin, a communication breakdown occurs within the nerves (IODCF, 2013). The gene for Serotonin is located at SLC6A4. That gene can be found on the q arm of chromosome 17 at location 11.2 (Gene Cards, 2014). Serotonin deficiencies are also related to other anxiety-related disorders…
should talk to your doctor first before using. The entire purpose of Prozac is to cure depression is youth and adults, it is supposed to treat all major disorders even suicidal ones. Prozac’s real name is Fluoxetine, which means it is an uptake of serotonin in the brain to help treat disorders of depression (Fluoxetine (Prozac)). Overall the medication is supposed to be the most effective, compared to other alternatives, but certainly should be discussed with a healthcare provider and is still…
Depression is an emotional state which can be characterised by, a heightened sadness; overpowering feelings of worthlessness; remorseful, lack of desire to socialise with others; sleeplessness; lack of appetite; loss of libido, and lacking interest in everyday activity (ref). It is believed to affect approximately 5-10% 0f the population in the United Kingdom (UK) Waraich, Goldner, Somers, and Hsu, (2004). As can be evidence from these symptoms individuals will have periods of times in their…
more. Abilify® uses a different mechanism from other drugs that have been approved for the same symptoms. The majority of antipsychotics shut down dopamine receptors. Abilify® works by making the receptors work properly, and is believed to act on serotonin…
Fragile X is a syndrome that I had little to no knowledge about before the presentation that Denise Devine gave us. From the presentation, I learned an array of information that will be helpful in my future. Denise touched upon a few topics that are important when understanding Fragile X syndrome. Fragile X the most common forms of mental impairment and is an inherited syndrome that is one of the leading developmental disabilities. One significant fact that is surprising is that Fragile X became…
such as avoidance, re-experiencing, and hyperarousal. SSRIs are tolerable and have few side effects. Serotonin-norepinephrine reuptake inhibitors block the reuptake of the neurotransmitters. SNRIs such as duloxetine, venlafaxine, and desvenlafaxine act by preventing the reuptake of the neurotransmitters serotonin and norepinephrine (Greenberg, 2012). High concentrations of extracellular serotonin and norepinephrine can improve mood and decreased depressive symptomatology (Greenberg, 2012). The…
Exercise: The Value of Exercise in Treating Depression Anxiety and depression are the two leading types of reported mental health illness in the United States. They are two sides of the same insidious coin, and affect around 40 million people each year, or 18% of the population. (ADAA) The advent of anti-depressant drugs has created a multi-billion dollar industry that argues medication is the most effective treatment for patients. And while antidepressants are an important option to have…
Major Depressive Disorder Major depressive disorder is a mood disorder that is caused by extreme and repetitious feelings of desperation, worthlessness, and discouragement. Most of these feelings are known to cause impaired emotional, cognitive, behavioral, and physical functioning or performance. (NEED CITATION) Major or clinical depression is commonly diagnosed with those who have the symptoms every day for at least two weeks. DSM-5 (Diagnostic and Statistical Manual) is a common tool…