Salicylic acid

materials, salicylic acid and acetic anhydride react causing aspirin to form. The oxygen of the acetic anhydride carbonyl is protonated, and the oxygen of the phenol group does a nucleophilic attack at the carbonyl that is protonated. The double bond between the carbonyl is broken causing a tetrahedral intermediate to form. Acetic acid leaves, and the carbonyl group is formed again. The remaining proton on the carbonyl oxygen leaves and aspirin is now formed. For the experiment, salicylic…

taken from the willow tree had harsh effects on the body and stomach. Throughout the 1800’s many chemists attempted to covert salicylic acid into a form that would provide the same medical benefits without the side effects. In 1852, Charles Gerhart was the first to attempt to acetylate the hydroxyl group thus creating acetylsalicylic acid. However the acetylsalicylic acid product…

percentage yield and purity of Aspirin made using a sulphuric acid catalyst and microwave method. ________________________________________ Aim To investigate the differences in purity and percentage yield between different types of aspirin; aspirin synthesised using a sulphuric acid catalyst, aspirin synthesised using a microwave, store bought aspirin and pure aspirin. The purity will be determined by the percentage acetylsalicylic acid found in each sample using different purity tests.…

The theoretical yield of acetylsalicylic acid in grams that should be obtained from the synthesis is 3.96 g. The closest experimental yield was obtained without using a catalyst for the reaction; with a yield of 3.67 g (93%) of crude acetylsalicylic acid and a yield of 3.39 g (86%) of recrystallized acetylsalicylic acid. These results are relatively accurate. Similar results were obtained for the experimental yield of the reaction catalysed by concentrated sodium hydroxide; with a yield of 3.38…

The goal of this experiment was to perform a synthesis of aspirin/ acetylsalicylic acid from salicylic acid, using a chemical synthesis procedure. The synthesis involved breaking the bond with acetic anhydride, also required heat and a catalyst, phosphoric acid, in order to beak and extract the bond. The solution used water in order to purify the solution in the way of recrystallization. The product was characterized using IR spectroscopy and melting point. The pure aspirin product that was…

Aspirin is produced from the reaction of Salicylic Acid and Acetic Anhydride. Aspririn is a analgesic and antipyretic. The purpose of this experiment is to produce aspirin and analyzing it for yield. Twenty grams of salicylic acid, molecular weight 138.1g/mol, 5.0 mL of acetic anhydride, molecular weight 102.1g/mol and density 1.08g/mL, and 5 drops of concentrated sulfuric acid were mixed in a 125mL flask. The mixture was heated in a 70°C hot water bath then taken out to cool to room…

medicine, Aspirin. Aspirin is the common name but it can also be known as Acetyl Salicylic Acid. Aspirin came to be because the hard work of scientist who were trying to relieve pain and fight fever without the patient suffering deadly side effects. A breakthrough occurred when a chemist named Felix Hoffman knew that phenolic compounds are corrosive because of the free hydroxyl group located on the benzene ring of salicylic acid. He then masked the hydroxyl group by replacing the hydrogen with…

purify aspirin. The experiment also allows students to carry out the synthesis of aspirin, build up their skills on recrystallisation and build up their recrystallisation techniques. To prepare aspirin, acetic anhydride was added to salicylic acid, after which, sulfuric acid was added and heated for some time to allow the reaction to be completed. On top of the addition of distilled water, cold water was also added. With the use of suction filtration, a crude product was obtained. The crude…

Synthesis of Aspirin Equipment: Salicylic acid 3.00g, 6 cm3 acetic anhydride, buncher funnel, timer,250 cm3 flaskProcedure: In order to synthesis aspirin the following procedure needs to be carried out. Firstly to being you would have to weigh 3.00g of salicylic acid and move it into a 250 cm3 flask that contains no moisture at all. You would then add 6 cm3 of acetic anhydride as well as 5 to 8 drops of 85% phosphoric acid to a flask. You would then need to gently mix the solution which is in…

Aspirin is a widely used over-the-counter pain reliever/fever reducer. Chemically aspirin is known as acetylsalicylic acid, it is formed when acetic anhydride and salicylic acid react with the addition of phosphoric acid, which behaves as a catalyst. (French et al. 82) The purpose of this experiment was to react acetic anhydride with salicylic acid to produce pure aspirin and acetic acid, a by-product of the reaction. At the completion of this reaction the mass of pure aspirin produced can be…