Salicylic acid

The theoretical yield of acetylsalicylic acid in grams that should be obtained from the synthesis is 3.96 g. The closest experimental yield was obtained without using a catalyst for the reaction; with a yield of 3.67 g (93%) of crude acetylsalicylic acid and a yield of 3.39 g (86%) of recrystallized acetylsalicylic acid. These results are relatively accurate. Similar results were obtained for the experimental yield of the reaction catalysed by concentrated sodium hydroxide; with a yield of 3.38…

The goal of this experiment was to perform a synthesis of aspirin/ acetylsalicylic acid from salicylic acid, using a chemical synthesis procedure. The synthesis involved breaking the bond with acetic anhydride, also required heat and a catalyst, phosphoric acid, in order to beak and extract the bond. The solution used water in order to purify the solution in the way of recrystallization. The product was characterized using IR spectroscopy and melting point. The pure aspirin product that was…

Aspirin is produced from the reaction of Salicylic Acid and Acetic Anhydride. Aspririn is a analgesic and antipyretic. The purpose of this experiment is to produce aspirin and analyzing it for yield. Twenty grams of salicylic acid, molecular weight 138.1g/mol, 5.0 mL of acetic anhydride, molecular weight 102.1g/mol and density 1.08g/mL, and 5 drops of concentrated sulfuric acid were mixed in a 125mL flask. The mixture was heated in a 70°C hot water bath then taken out to cool to room…

medicine, Aspirin. Aspirin is the common name but it can also be known as Acetyl Salicylic Acid. Aspirin came to be because the hard work of scientist who were trying to relieve pain and fight fever without the patient suffering deadly side effects. A breakthrough occurred when a chemist named Felix Hoffman knew that phenolic compounds are corrosive because of the free hydroxyl group located on the benzene ring of salicylic acid. He then masked the hydroxyl group by replacing the hydrogen with…

Purpose The purpose of the experiment Thin Layer Chromatography was to analyze compounds, Aspirin, a mixture of Tylenol with ethanol, acetaminophen, a mixture of Excedrin with ethanol, Aspirin, and acetaminophen, Anthracene, Benzyl, and Triphenylmethanol by separating them with the help of silica plates. Procedure Three silica plates were taken and on the plastic side, they were all marked 1 cm above its end using a pencil. With the help of capillary tube, the first and the second plates were…

Introduction The ferric chloride test is used to determine the presence of phenols in a given sample or compound (for instance natural phenols in a plant extract). Enols, hydroxamic acids, oximes, and sulfinic acids give positive results as well. The ferric chloride test can be used to detect metabolites in urine in case of inborn error of metabolism such as phenylketonuria. In addition,the Ferric Chloride test can be used to detect salicylates in urine after an aspirin overdose.1 Background…

In order to extract aspirin, caffeine, and acetaminophen from a tablet of pain medication acid and base extraction techniques were used to exploit the differences in solubility between the components. This is achieved by using a separatory funnel and three different solvents, 4M HCl which separated the caffeine, deionized water which separated the acetaminophen, and 5% wt/vol NaHCO3 which separated the aspirin. Once the solution of the crushed tablet and ethyl acetate was mixed with a solvent in…

concentrated sulfuric acid in the first step? The purpose of using concentrated sulfuric acid is to activate the reaction of salicylic acid and acetic anhydride and produce the acetylsalicylic acid, which is aspirin. The sulfuric acid is used to protonate oxygen atom of a carbonyl group of salicylic acid. 2. What would happen if the sulfuric acid were left out? Removal of catalytic acid from the reaction would slow down or not proceed at all because the phenol group on salicylic acid is not…

system, and ionic character of solute. Ionic character and pH were manipulated to increase solubility favorability of the compound in extraction solvent. In essence, pH is the easiest factor to manipulate because it merely involves using an aqueous acid or base as an extraction solvent that simultaneously abides by the four solvent requirements of extraction. In regard to recrystallization, an impure compound is allowed to dissolved into a solvent and then allowed to reform as a pure solid…

Purpose: Determine the percentage of 2-ethanoylhydroxybenzoic acid in aspirin tablets. Introduction (including background information) : Before creating Aspirin, “sail alba” was used. In 1860’s, chemists discovered that Salicylic acid (2-hydroxybenzoic acid, C7H6O3 ) is the active acid in sail alba. Salicylic acid is relatively strong though. It can irritate and damage the stomach membranes and mouth. In 1889, ethanoate ester of salicylic acid was introduced by the Bayer Company. They named it…