RNA interference

Some of the more prevalent comorbidities are joint pain and clinical depression. According to Weigle, patients reported low self esteem , reduced social interactions, reduced income and a general interference with daily life. Patients also reported high incidence of depression and loss of trust in their treatment team (Weigle, 2013). Psoriasis can be difficult to treat because the causative factor for the skin lesions is a malfunctional immune response…

it from degrading the mitochondrial membrane that result in caspase-induced apoptosis. Furthermore, activation of AKT pathway signals Rheb that triggers mTOR activation translation factor S6K, which binds to the large ribosome subunit and promotes RNA translation (Davis et al., 2014). This suggest that AKT activation enables cell proliferation by inducing increased protein translation and cell growth. The activated AKT pathway also promotes phosphorylation of the tumor suppressor FOXO that…

Cognition is defined as a group of higher order brain functions which includes language, emotion, memory, and consciousness. (Purves, 2012) Aside from leading to severe immunodeficiency (AIDS), the HIV-1 lentivirus can also lead to a spectrum of emotional and behavioral disturbances collectively known as HIV-associated neurocognitive disorder (HAND). While antiretroviral therapy, such as highly active antiretroviral therapy (HAART), has managed to increase the life expectancy of infected…

According to Simon and Farndon (2008), genetic disorders are abnormalities in an individual 's gene or set of genes which could be due to mutations in the DNA. Also, there are thousands of genetic diseases that can occur as it is estimated that the average rate of genomic mutation is about 2x10-8 per nucleotide per genome (Nachman and Crowell, 2000). Furthermore, they can be grouped into three types named single gene disorders, chromosomal disorders and multifactorial conditions (Milewicz, 2007)…

Huntington’s disease (HD) is a late-onset, usually between 35 and 50 years old, neurodegenerative disorder prevalent in 3-7 per 100,000 people of European ancestry1. The disease, inherited in an autosomal dominant pattern2, is characterized by motor disturbance, intellectual decline, and psychiatric manifestations3. The disease is difficult to detect at an early stage of an individual’s life since its symptoms appear in the third to fifth decade of life. To better understand the disease,…

The potential for the inhibition of anti-apoptotic and RNAi pathways to enhance in vitro baculovirus biopesticide production Summary Baculoviruses are target specific virus infected a number of plant pests especially the lepidopterous pests. Baculovirus biopesticides have been used worldwide for decades. Although many have been done to enhance yields of baculovirus in vitro production, their large-scale production poses certain difficulties that limited the use. Apart from optimization of cell…

Revolution against the basic evolutionary developmental biology arises with the astounding repair capacity of the planarian robust self assembly system and its automatic repair ability of its body structures. With its complex body plan and nervous system, a planaria possess the ability to flawlessly regenerate any part of their body after a traumatic injury or loss. It is capable of recovering its original structure and function of any damaged or obliterated body part even after being deprived…

Mesalazine and Rifaximin use for Inflammatory Bowel Disease. Mesalazine is used as in anti-inflammatory agent, Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients.…

In cell theory, it is known that all cells arise from pre-existing living cells, through cell division. In cell division, this involves the supplying of identical genetic material from the parent cell, DNA and protein, to two daughter cells. It results in the daughter cells having the same number of chromosomes as the parent cell. We need cell division as it is used in reproduction of new species, growth and repair of damaged cells and tissues, and to reduce the cell size. Larger cells are…