Receptor antagonist

Examine the forced swim test and sucrose preference test as simple tests of behavioural despair in a rodent animal model of depression, and evaluate the efficacy of nAChR agonists, antagonists, and ligand agonists as a supplement to the commonly prescribed antidepressant fluoxetine. 1.1 Rationale & specific goals The forced swim test (FST) and sucrose preference test (SPT) are commonly used behavioural experiments that are low cost, simple to implement, require no training of subjects, and can…

These opioid receptors are found in the cortex, amygdala, hypothalamus, thalamus, hippocampus, and the peripheral sensory neurons. Brain parts like these are affected because they are involved in emotion, memory, hormone production, sensory processes like seeing or smelling…

have for so long. Marijuana contains more than 100 neuroactive chemicals the work with two types of cannabinoid receptors, type 1 (CB1) located in the brain and type 2 (CB2) located in the peripheral immune system. (Parkinson.org 2) There are two different molecules that interact with the plants receptors called agonists and antagonists. They both collaborate by sending a natural receptor that causes the “calming effect”. Therefore, releasing a chemical release throughout the body, giving the…

dopamine in the nucleus accumbens. Acute alcohol intoxication leads to an incentive motivation as the firing of dopamine is decreased during withdrawal leading to a desire to drink to fire dopamine once again. Endogenous opioids interact with opioid receptors leading to a sense of euphoria. Seeing that alcohol increases the release of such opioids, naturally produced in the body, it is speculated that the opioid system is the main contributing factor to the addictive properties of alcohol. The…

This can help clear away mucus and keep the nasal passages moist. Medicines to block an allergic reaction and inflammation. These may include antihistamines or leukotriene receptor antagonists. Repeated exposure to tiny amounts of allergens (immunotherapy or allergy shots). This helps build up a tolerance and prevent future allergic reactions. HOME CARE INSTRUCTIONS If you know certain allergens trigger your child's condition…

In mice, pain decreased with the administration of Naloxone, an opioid non-selective antagonist, plus IBLEO (p < 0.001). However, administration of selective opioid antagonists (Naltrindole, Nor-binaltorphimine, and Naloxonazine) attenuated the antinociceptive effect of IBLEO (p < 0.001). Both methylene blue and Glibenclamide blocked the antinociceptive effect of IBLEO (p < 0.05)…

Depression is a brain disorder which generate major disability. Its etiology and molecular mechanism is not fully understood. It is a leading cause of disability globally, with lifetime prevalence as high as 20% (Kessler et al., 2005). Depression is multifactorial disorders that differ in symptomology and most possibly in etiology. There are various symptoms of depression include depressed mood, mood swing, loss of pleasure activities (anhedonia), inability to concentrate, lack of energy,…

1. The name of the drug The generic name of the drug that is the theme of this assessment is Metoprolol succinate. The trade names this drug is known as in New Zealand is Betaloc CR and AFT-Metoprolol CR (AFT-Pharmaceuticals Ltd, 2009); AstraZeneca Limited, 2014). 2. General classification of given drug This drug is an antihypertensive medication and a beta1-selective beta-blocker (AstraZeneca Limited, 2014). 3. Indication of use and purpose of given drug Jack is taking Metoprolol succinate…

Caffeine Specific Purpose: To inform my audience of a popular stimulant that contributes to many Americans daily lives. Central Idea/Thesis Statement: Today I will be informing you about caffeine, and extravagant drug that most Americans cannot live without. At the end of this speech, I hope that you have learned three things: what is caffeine, how does it work in our body, and what are the pros and cons of caffeine consumption. INTRODUCTION I. Attention Getter- We have all heard the saying…

Chronic depression, also referred to as dysthymia or chronic depression is a mood disorder. Chronic depression is defined any feelings of hopelessness and unhappiness that persists for more than two weeks, and it is different from psychotic depression. With psychotic depression, the illness is accompanied by some form of psychosis, such as delusions, detachment from reality, and hallucinations. In addition to emotional disturbances, chronic depression is also like to sensory disturbances, such…