Pyrimidine

The RNA World: The Implications and Problems it Presents Brandon Gutierrez Abstract The origin of life on Earth is a difficult topic to analyze with the limited data available in modern science. Many hypothesis have been suggested to explain how life may have arisen from an abiotic environment, but the topic is still far from fully understood. One generally accepted hypothesis to explain the origin of life involves an RNA world in which RNA was synthesized abiotically and carried out both the…

in Influenza A 4. Integration of the viral DNA into chromosomal DNA of the host cell: Can be blocked by Fomivisen e.g in Cytomegaloviruv. 5.Template production and RNA or DNA replication (Nucleic acid synthesis) . This Can be blocked by purine,pyrimidine analogs and reverse transcriptase inhibitors. 6. mRNA transcription , processing and translation of mRNA to protein : blocked by Methisazone e.g in Variola 7. Post-translational modification of proteins: 8. Assembly of the components into the…

Methotrexate is a drug used to treat cancer, psoriasis, rheumatoid arthritis, lupus, and to induce miscarriage in women who have had ectopic pregnancies. Question 1: Pharmacokinetics describes how the body affects a certain type of drug after administration through absorption, metabolism, distribution and excretion while travelling throughout the body. Absorption Absorption is defined as the movement of a drug through the bloodstream. Absorption of a drug is affected by the solubility of the…

Deoxyribonucleic acid, or DNA, has become one of the most significant discoveries known to humans. The DNA of an individual is located in the nucleus of the cell and it is the same in every cell. DNA is the genetic makeup of an individual and it is unique to them, meaning, no one has the same genetic code of adenine, cytosine, guanine, and thymine. Every person and living thing have a unique genetic code and sequence of the four chemical bases. DNA has been evolving since the beginning of time…

Anthony Alvarado Bio 1A Chronic oxidative stress via hydroxyl radical and imbalanced redox homeostasis Redox hemostasis has been shown to be an important factor in the overall aging and neurodegeneration processes in mammalian models; such as, Alzheimer’s and Parkinson’s. As a result, redox homeostasis has been a key point of interest in current research. Redox homeostasis is the balance between electrophiles and nucleophiles in a system, more importantly in a biological system. These…

We determined that the UV light treatment was the most potent treatment of mutagenesis and also the most effective in inducing mutations, followed by the Tn5 and the EMS was the least potent and effective treatment. Introduction A culture of E.coli K12, KL14 was used to carry out the experiment on. The advantage of using E.coli cells to experiment on is that they are haploid organisms and contain a single set of chromosomes so if a mutation was to occur, the bacterial cell will express it as…

through which Pralatrexate, though not necessarily other anti-folates, enters the cell. This carrier protein has evolved to efficiently transport reduced natural folates into highly proliferative cells, in order to meet he demands for purine and pyrimidine nucleotides during deoxyribonucleic acid (DNA)…

Introduction Cancer is a disease whereby cells undergo changes that cause them to grow uncontrollably1. These changes are caused by gene mutations2. Genes are sections of deoxyribonucleic acid (DNA), contained within every cell2. Genes control which proteins are synthesised and which cells should be destroyed2. Each type of cancer is classified according to the site where the cancer initiated, i.e. the location of initial gene mutation3. Malignant melanoma is a skin cancer whereby the…

The Family Tetraodontidae and its Toxic Defense Mechanism Tetraodontidae, a family commonly known as the pufferfish, uses unique defense mechanisms in the wild to protect themselves against predators. Pufferfish diet consists mainly of invertebrates, so they are not viewed as dangerous or predatory animals in their ecosystems. These defense mechanisms are necessary to the survival of the Tetraodontidae family. The Tetraodontidae family’s defense mechanisms of inflation and use of the deadly…

Sirtuins and Histone deactylases (HDACs) Eukaryotic DNA is packed in a high level structure called chromatin, resulting from the assembly of an elementary unit, the nucleosome, and an octameric structure obtained from eight proteins called histones [1]. Histone deacetylation is a reversible process whereby histone and non-histone protein transfer the acetyl moiety from acetyl co-enzyme A (CoA) to lysines while histone acetylation is the direct opposite process whereby acetyl groups are removed…