Pyrimidine

Abstract: Four sets of new triterpenoids, were prepared from allobetulon, methyl betulonate, methyl oleanonate, and oleanonic acid. First, a thiocyano substituent was introduced at the C2 of each terpenic 3-oxo derivative, which was followed by cyclization with appropriate ammonium salts to form N-substituted thiazole. All 42 new compounds were tested for their in vitro cytotoxic activity on eight cancer cell lines and two non-cancer fibroblasts. Intermediates 2b, 3b, 5b, and 5c were best with…

disease impairs the ability of the body to repair DNA which is damaged mainly by Ultraviolent light as well as various chemical Carcinogens. ” The most common forms of DNA damage occurs via the cross linking of adjacent pyrimidines resulting in the formation of cyclobutane pyrimidine dimers (CPDs)” (1) for example UV light will often make two T 's bases next to each other bind making a dimer. The regions of the cells that are affected by the disease are called the nucleotide excision repair…

FLUCYTOSINE Also known as 5-flurocyrosine or 5-FC. It’s an antifungal drug that is usually formulated with amphotericin for wide range of medical uses, it can be used by mouth for treatment of infections that could be caused by Cryptococcus neoformans or perhaps candida. It could also be used in the treatment of chromblastomycosis (chronic fungal infection of subcutaneous tissue or skin). Because of its weak antifungal action it can’t be used alone for treatment of serious, life threatening…

material is carried on from one generation to the next. Nucleotides join together through phosphodiester linkages between the 5 ' and 3 ' carbon atoms to form nucleic acids. “Nucleotides are composed of a five-membered sugar group with a purine or pyrimidine nitrogen base group attached to its 1 ' carbon via a glycosidic bond and one or more phosphate groups attached to its 5 ' carbon via an ester bond” (sparknotes.com/biology). DNA and RNA both contain genetic information, however there several…

Goals E. coli is a type of bacteria that sense and swim towards sugar, amino acids, pyrimidines and electron acceptors. Thus, the goal of this experiment was to determine whether E. coli has a direct motion or random motion when a chemoattractant (glucose) was present. This was done by observing the velocity before and after the chemoattractant and by making Log-Log Plot. Theoretical Chemotaxis refers to the ability of organisms to move in response to the presence of a chemical. The movement…

Case Summary, including Signs and Symptoms This case study aimed to shed light on the importance of rapid detection of microorganisms using an efficient technological development, Matrix-assisted laser desorption ionization, Time-of-flight and Mass spectrometry (MALDI-TOF MS). The case involved a 54 year old Asian male who had received a living-donor kidney transplant 14 years ago due to IgA nephropathy. Signs and symptoms included, fever, multifocal cellulitis, bacteremia, swelling and…

In recent years MTHFR has been popularised in social media and blogs with various levels of information and potential misinformation. A search on google.com.au using the term “MTHFR” provided 1,330,000 results in 0.40 seconds.[1] With all of this different information being available 24 hours per day, all year round, it can be confusing for practitioners and patients to sift through to determine what is scientific, clinical or “hearsay”. 5,10-methylenetetrahydrofolate reductase (MTHFR)…

When DNA absorbs the radiation at 254 nm, the cell utilizes that energy to form new covalent bonds between the pyrimidine dimers, which alter the DNA and impede with proper replication and transcription processes. Baring E.coli at 20 minutes, all species had some form of growth when sheltered from the UV light, which was expected because there are less harmful effects…

Deoxyribonucleic acid is known as the molecule of inheritance where its structure dictates its function in storing the genetic information of the organism (Rafael, 2010). This molecule contains genes which encode proteins needed for the complex biochemical metabolic reactions which occur within the organism (Rafael, 2010). The DNA molecule consists of 2 complementary strands in a helical structure where each strand serves as an informational template for the offspring during duplication (Rafael,…

An example of this would be Chargaff’s Rules which, states that DNA from any cell of an organism should have a 1:1 ratio of pyrimidine and purine bases. When this claim was first made in 1950, it was not proven until many years later. Ruse counter-argued this statement by claiming that scientific explanations appeal to laws. “We are not, however, contending that a departure from…