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Alexis Arciga Biol 125 M‐TH 9:30‐12:50 Parkinson’s Disease Parkinson’s disease is an illness that if diagnose can be persistent for the rest of your life. As the disorder progresses the symptoms become more severe. Trembling of the hands and feet occur, stiffness in the body and involuntary shaking occurs. This is due to the deterioration of the nervous system caused by lack of dopamine in the human brain. Doctors have been trying to figure an alternative to diagnose PD such…

C. APPROACH: C.1. Experimental rigor: We will apply our established in vitro and in vivo analyses to the studies proposed in both aims (31, 41, 42). Our preliminary data demonstrated the vigorous infection in both Heterozygotes (Foxn1nu/+) and homozygotes (Foxn1nu/nu) NU/J mice at mucosal sites. To minimize the possible variations in the animals, we will use siblings of these two inbred mouse strains. For the experiments proposed in both specific aims, we will use fifteen animals in each group…

ATF3 function in cancer cells: oncogene vs. tumor suppressor The mouse homolog of ATF3 (named TI-241) was identified by differential hybridization due to its high expression in the extremely metastatic melanoma cell line B16-F10, and absence in the related but non-metastatic cell line B16-F1. While characterizing the ATF3 mouse homolog, it was found that over-expression of ATF3 in the non-metastatic B16-F1cells converted them into highly metastatic cells, therefore, suggesting that ATF3…

Lung Cancer Lung cancer is a malignant neoplasm of the lung tissue characterized by an uncontrolled cell proliferation. It is also referred to as carcinoma of the lung. This neoplasm arises from epithelia of the lungs, bronchi and trachea. Lung cancers can be of epithelial cell origin (carcinoma) or mesothelial cell origin (malignant mesothelioma). Lung cancer begins with inactivation of tumor suppressor genes or with activation of oncogenes. Carcinogens bring about mutation in the genes that…

The Cancer Stem Cell Hypothesis: A Basic and Clinical Approach to Treating Glioblastoma Multiforme Introduction Glioblastoma (World Health Organization grade IV glioma; GBM) is the most prevalent and malignant primary brain tumor in adults, and it is predominantly drug and radiation resistant1. Unlike many other solid tumor types, GBM extensively invades the surrounding brain, but it rarely metastasizes to other organs. Beyond its invasive nature, there are a variety of other hallmarks of…

1. Introduction: Squamous cell carcinoma of the head and neck (SCCHN) can be ranked as the sixth leading cancer by incidence worldwide (1,2). Every year, there are more than 550,000 patients diagnosed with head and neck cancers worldwide and around 300,000 related deaths (3). Squamous cell carcinomas represent 90% of cases and mostly arise from the epithelial lining of the oral cavity, oropharynx, larynx, and hypopharynx. SCCHN can be divided into three stages: early stage (I/II), locally…