Proton NMR

was identified as pulchranin A with ESI-MS in positive ion mode [M+H]+ ion of m/z 256.19 and a molecular formula of C14H29N3O(Guzii et al., 2013). 1H and HSQC NMR data (DMSO-d6) revealed the presence of nine methylene groups, an N-substituted methylene at C-3 (δC 53.2; δH 3.73), a guanidine group showing two singlets and one triplet proton signals ( δH 8.52, 7.46, and 7.49), an OH group at C-6 (δH 3.95), one terminal methyl group at C-15 (δH 0.86; δC 14.0), a double bond between C-5 and C-6…

Temazepam, commonly known as Restoril, is a sleeping pill that is prescribed to patients. This drug is classified under a type of drugs called benozaphines, which are, “a large group of drugs with sedative and anxiety-reducing properties, which have been found valuable for a large number of uses” (UXL Encyclopedia of Drugs and Addictive Substances). This class of drugs is used to reduce anxiety and help with insomnia. Since temazepam is classified as a benzodiazepine, I was curious as to what…

In the FTIR spectrum of Cy4P1+BF4-, the peaks at 1633 and 3432 cm-1 belong to water because of its strong hygroscopic nature. In the 1H-NMR spectrum of Cy4P1+BF4- (Figure S2), δ = 2.95 and 2.63 ppm are attributed to the CH and CH3 protons; the peaks in the region δ =1.00–1.90 ppm are assignable to the CH2 protons in cyclohexane. The integrated areas of three protons indicate the presence of CH3 and cyclohexane groups. The single peak…

the bore. But this isn't just any magnet; it’s an incredibly strong system, one capable of creating a very large and stable magnetic field. Since your most of your body consists of water, which contain oxygen and hydrogen. Hydrogen holds protons, and these protons are what get affected by the magnetic…

for organs such as brain, eyes and heart. Also, the MRI scans are extremely useful for creating images of soft tissue structures, such as ligaments and cartilage. This is because the MRI machine works by detecting protons and every bodily structure has a different alignment of protons. In contrast to this there are also many disadvantages to the MRI machine; however, these disadvantages are not life-threatening and are very subjective for the patient. The first disadvantage is the really strong…

There are several different reactions that can be utilized in order to end with a product that includes the synthesis of carbon-carbon bonds, however for this experiment the reaction that was utilized is aldol condensation. An aldol condensation is when an enolizable aldehyde or ketone undergoes a reaction, in the presence of a base or acid, and gives a beta unsaturated ketone or aldehyde (Utah Valley University, 2009). This type of reaction can also add carbonyls to a compound, using similar…

(Isopentyl acetate) from the reaction of Acetic acid and Isopentyl alcohol by the Fischer Esterification reaction. By using the methods of refluxing, washing, drying, and simple distillation to purify the end product. When the product was isolated an IR, H NMR and boiling point were used analysis the product, the end product had a banana like odor. Reaction Scheme: Mechanisms Procedure: In the Jane Wissinger Laboratory Manual for Organic Chemistry 2311 (A Greener Chemistry Approach) on…

INTRODUCTION In the recent advancement of targeted therapeutics that was coupled with new approaches in target identification have accelerated the need to design small compounds with drug like properties [1]. Quinoxaline is well known for its broad coverage in the field of medicine as well as for its application in the pharmaceuticals as they have shown wide range of biological properties such as antimicrobial [2], antibacterial [3], antitubercular [2, 4], antiprotozoal [5] , anti-candida [2, 6]…

In this study, we developed an anthracene-based fluorescence PET sensor (AMG) was developed for detecting high pH values and water content in organic solvents. A guanidine group as a proton receptor was covalently attached to an anthracene fluorophore to afford highly polar AMG, with reasonable solubility in highly basic solution. The fluorescence of AMG increased almost linearly with decreasing pH in the range 11.0–13.0. AMG also exhibited a fluorescence turn-on response to water in various…

unity with the observed values. Detailed interpretations of the infrared and Raman spectra of 2NAP are reported. The theoretical spectrograms for FT-IR spectra of the title molecule have been constructed. The 1H and 13C nuclear magnetic resonance (NMR) chemical shift of the molecules are calculated by the gauge independent atomic orbital (GIAO) method and compared with experimental results. Further, density functional theory (DFT) combined with quantum chemical calculations were done to find out…