Progressive multifocal leukoencephalopathy

of millions of euro. (1) For every drug that gets approved by the Food and Drug Administration (FDA) in the US, 5,000 to 10,000 compounds don't make it through the process, making the whole process very costly and financially risky. (1) A drugs lifecycle ends when or if it is taken off the market unless as in the case of natalizumab it is put back on the market again. The development of natalizumab is a unique story. It is a recombinant humanized monoclonal antibody that binds to the α4 integrin and is used to treat multiple sclerosis (MS). It was granted approval in 2004 by the FDA, only twelve years after its molecular target was cloned. (2) Unfortunately, several patients treated with natalizumab were diagnosed with progressive multifocal leukoencephalopathy (PML) after its initial approval, and the sale of natalizumab was suspended. The drug was reintroduced to the market in…

and reformed into a powerful machine of industry. But as the economy and boomed, society rotted and decayed. Poverty was rampant everywhere and death infested the cities. The Progressive Era served as a time in which the wrongs of the Industrial Revolution were righted. Journalists, politicians, suffragists, and more rallied to clean the filthy and corrupt machine the US had become. Nellie Bly was a member of the Progressive journalists, a muckraker, and made a great impact in reforms. Because…

seek the help of the wealthy but the wealthy themselves agreed to support his vision as well. As Washington began to receive donations from less fortunate donors, others began to realize the attempts of growth in his institution and therefore donated larger amounts to his establishment. He took advantage of the fact that “the rich people are coming to regard men and women who apply to them for help worthy objects” (Washington, 90). Carnegie as well as various other wealthy donors acknowledged…

progressivism. Progressivism is often used to describe a number of reactions to the economic and social problems and the political, social, moral and economic reforms that came with these responses. This essay focuses on the progressivism, the progressive era and the changes that the movement brought to America. Progressivism was started as a social movement and later turned into a political movement. Progressives were people who believed that the issues and problems in the society were solvable…

Prior to the Progressive Era, industrialization, urbanization, and immigration had quickly changed the nation in dramatic ways, to such an extremity that Progressives believed the only way to fix problems was through government involvement. The political progressive reforms beginning in 1890 and further were mostly successful, even though some yielded muddled results. As a whole, many beneficial improvements were able to rise out of the Progressive Era that aided in ameliorating and shaping the…

history during the progressive era. Robert Wiebe, Richard White, Michael McGerr, and Robert Zieger were the authors who shared their knowledge with those interested in learning more about what transformed our country from the late nineteenth century and into the twentieth century. First, there is a need to understand what progressivism means. All four authors touch on the era in their books, but Michael McGerr’s story shared a simpler explanation. McGerr shared American’s personal stories…

DBQ The Progressive Era, 1900-1920, can be defined as a reform movement aimed toward urban and social change through improvements in the nation. This era stemmed from American industrialization and a population growth. Also, the Progressive Era emerged from past movements such as abolitionism, women’ rights, temperance, and the regulation of big businesses. Some of the main goals of the progressives included breaking trusts, ending political reform, bettering living conditions, and establishing…

Module 3 Discussion Why were so many different Americans willing to embrace a new role for the federal government during this time? The Progressive movement changed many Americans and the idea of the federal government having power over the people. In reading the chapters, video and articles, my perception of the Progressives is that they were interested in having what they called “good government.” By having this reform implemented of a good government, the Progressives would create a type…

Transcendentalists believed in multiple interesting things that could possibly change people’s lives. These interesting people believed in things such as civil disobedience, nature, and self-reliance. They flourished during the 1800s in the United States of America. The songs I will be comparing Transcendentalism to are “Spring Day” by BTS, “Thunder” by EXO, “Gotta Go My Own Way” by High School Musical, and “Love Myself” by Hailee Steinfeld. Transcendentalists were very keen on the idea of…

INTRODUCTION Taxation can be defined as act of legal authorities of imposition of tax on commercial and non-commercial transactions. Individuals and business entities are liable to pay tax charges for the profit or benefit earned by them through operational activities in timely manner. Tax is levied in UK on the basis of statutory norms described by HMRC. Taxes is payable in UK at minimum three different level i.e. central government, local government and devolved national government (Citron,…