Prion infectious diseases: History and molecular pathology
It is circa 500 BC, and Hippocrates records rare but localised outbreaks of madness within livestock; he observes that the animals’ neurological capabilities rapidly decline after years of apparent normality. When he investigates, he finds that the brains of these animals are ‘very full of dropsy and of an evil odour’. He hypothesises that this disease would be able to spread and infect humans too (McAlister, 2005). To him, this is obviously not a product of Gods like the common ideas of infection at the time, instead he describes it as ‘organic’.
It is 1755, farmers in Britain watch their sheep go into hysteria, rubbing their hind-quarters against fenceposts and rocks until they…
Hunting is often portrayed purely as a form of sport or the quest for a big trophy. But what most people do not acknowledge is that it does much more for the human population in general. Hunting provides us with the resources that allow us to live comfortably. Not only does it do this, but it provides health to our environment as well as our economy. Hunting large game plays a vital role in the protection of our people, our resources, and the animals themselves.
To begin, the killing of large…
Dementia: Benefits of Brain Stimulating Activities
Dayla F. Doll
Dementia in itself is not a disease but the loss of mental function in more than two areas. Dementia is the loss of memory and other mental abilities that affect daily life. Dementia is a series of symptoms that accompany a disease. The dementia symptoms can affect
Memory loss and the loss of important functions of the brain, such as knowing how to eat, talk,…
Population Report on Dementia
The purpose of this report is to provide a brief overview about dementia which includes describing the demographics, characteristics, and challenges of the disease. Additionally, this report will explain current medical issues, non-music therapy treatment trends, and current effective therapeutic interventions regarding this type of population. It is understood that dementia is an umbrella term which encompasses a large variety of diseases, therefore the objective…
Bacteria, virus, and prions all play a part in our life, good and bad. Bacteria are forms of life that are considered living. That’s the difference between virus and prions, who lack the ability to reproduce once they are isolated. The reason behind that is because viruses and prions need a host to reproduce. Bacteria are single celled microbes. The cell is simpler than other organisms because there is no nucleus or membrane bound organelle. Bacteria’s genetic information is contained in a…
o “an infectious protein particle similar to a virus but lacking nucleic acid”
What is the abnormality in the nervous system?
• Normal prion proteins (PrPc) found in the membranes of neurons
o Produced in the endoplasmic reticulum, processed by Golgi Apparatus, and transported to the neural membrane
o Predominantly made up of alpha-helical configurations
• In abnormal prions (PrPSC): configuration is mostly made up of beta-pleated sheets
o These abnormal prions induce normal prions…
deposition on mRNA and other types of nuclear RNA. The dynamic regulatory roles of these types of mRNA that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing post-transcriptional regulation of gene expression.
Prions are the proteins of specific amino acid sequences in specific conformation. They proliferate themselves in host body by making variety of conformational…
10,1988. The poor management of medical waste resulted in the wash-up incidents on the Atlantic coast in 1987 and 1988. Following the incidents, the congress passed the Medical Waste Tracking Act of 1988. After a few years, many states responded to the wash-up crisis by formulating their own medical waste regulations. Consequently, New Jersey’s Regulated Medical Waste Management act was passed. This paper succinctly discusses New Jersey’s Regulated Medical Waste Management regulations.…
convicted of state crimes serve
their time in state prison, defendants that are convicted of federal crimes serve their time in
federal prison. Defendants that are convicted of minor crimes and sentenced to two years or less
serve their time in a jail. Because jails are considered to be short-term, state prisons and federal
prisons offer training and programs that jails do not offer. A county jail may offer work release
programs. State and federal prions also offer work…
possible because budding yeast has a very short gene sequence and its entire genome has been crafted. Budding yeast is a model organism in the genetic world. This is due to the yeast ability to take up exogenous DNA both artificially and naturally (Mitrikeski 2013). Yeast is able to take in exogenous DNA and become biologically stabile at an outstanding rate. This high ability for yeast to transform is evolutionary important because it allows the yeast to have a high degree of biodiversity…