Polychlorinated dibenzodioxins

“I have no future, no happiness” (“Eating, Drinking, Touching, Breathing, Nursing, Conceiving”). Do Duc Diu, a father who lost twelve out of his fifteen children from the effects of Agent Orange expresses how Agent Orange has changed the meaning of his life. The effects of Agent Orange are horrific. Any where from 2.1 million to 4.5 million Vietnamese citizens have been exposed from the time of spraying the dioxin-contaminated herbicide ("Health Effects of Agent Orange/Dioxin"). It has been…

Through going up in Green Bay and De Pere, Wisconsin, there has always been a topic that has continuously appeared and disappeared. That is the condition of the Fox River, throughout my childhood I was never able to fully use the river to swim or fish within. That is because of the dangerously high levels of pollution that are within the water. The river has been found to have 209 chemicals found in a study by Sharon A. Fitzgerald and Jeffrey J. Steuer. Throughout my studies, I have found great…

In my expert reports for the Fox and Kalamazoo matters, submitted in 2009 and 2015 respectively, I concluded that the weight of evidence prior to the time when NCR eliminated the substance from the paper did not indicate potential environmental hazards posed by the Aroclor 1242 in NCR CCP. I found that it was not credible to suggest that a company such as NCR had sufficient knowledge to be concerned about using a substance such as Aroclor 1242 in its CCP, especially in the absence of…

exceptions based upon the path that the hazards had taken. The following pollutants have been identified as having some long term impacts: Metals, polycyclic aromatic hydrocarbons , polychlorinated dibenzofurans, and polychlorinated dibenzodioxins, polybrominated dibenzofurans and, polybrominated dibenzodioxins, polychlorinated biphenyls and perfluorinated compounds (FM Global, 2010). Evidence shows that human health can be critically affected by forest fires. Smoke has high levels of crude…

Throughout history a strong correlation has been observed between the presence of environmental pollutants and adverse physiological effects on both humans and wildlife (Olea & Fernandez 2000; Kawai et al. 2003). These pollutants have the capacity to disrupt normal endocrine function, with the majority of cases involving reproductive abnormalities leading to population decline (Kawai et al. 2003). Chemicals with such effects are labelled as endocrine disruptors and can be defined as exogenous…

the reaction of TCDD with CYP1A1. The metabolism of polychlorinated dibenzodioxins (PCDDs) is in vivo (especially human beings) is mainly depended on the cytochrome P450 proteins, mainly on CYP1A1, CYP1B1 and CYP1A2.2 Focusing on CYP1A1, it utilizes a single oxygen atom to begin the reaction and to form a epoxide from PCDD. That is why it is known as monooxygenase (mono= 1, oxygen, ase= suffix for enzymes). Although polychlorinated dibenzodioxins (PCDDs) or dioxins have so many kinds, the most…