QUESTIONS 1. Discuss the pathophysiology of coronary artery atherosclerosis. Include discussion of risk factors associated with the development of this disease. (10 points) Coronary artery atherosclerosis is most commonly comprised of atherosclerotic fibrous fatty obstructions of the large epicardial vessels, which provide for blood flow and transport nutrients, oxygen, and elimination of metabolic waste products such as CO2, lactic acid, and hydrogen ions. Coronary artery atherosclerosis…
Mixed contamination of PAHs and metals occur ubiquitously in the environment, but their combined toxicity to humans and other organisms are not fully addressed. The data from epidemiological, animal and in vitro studies indicated the nature of interaction between PAHs and metals varies from synergism to additivity or antagonism. In this chapter, the combined toxicity of PAHs and metals on toxicokinetic and toxicodynamic endpoints, and possible mechanism of actions were discussed. In addition,…