Phosphonate

Over the last few decades technology has made great progress in the medical field, helping to discover new treatments and cures for problems affecting the human body. Anti-biotics are being used to fight off infection, multiple radiation beams are being used instead of just one for tumor treatment to help patients avoid harmful radiation, and many more that were thought impossible just a short while ago. But even in cases where there is still no definitive cure, technology has advanced so much…

It is also conceivable that, at lower pH, depurination can occur via protonation of the purine nucleobase at both N1 and N7. The presence of the 2′-OH has a significant effect on the nucleoside’s susceptibility to depurination. For example, guanosine and adenosine are more resistant to depurination compared to deoxyadenosine and deoxyguanosine. Deoxyadenosine itself depurinates 1200 times faster than adenosine (York, 1981). Interestingly, N-acyl-protected purine nucleosides (particularly…