Penicillium

As years have gone by, the quality of life of human beings has been dramatically improved through the discoveries of some of history’s greatest scientific minds. A major contributor of the impact of science on the today’s world was Sir Alexander Fleming, known to most people as the “Penicillin Man.” Alexander Fleming was born in Ayrshire, Scotland, on August 6, 1881 (Biography.com Editors). Sir Alexander Fleming was a doctor and bacteriologist most notorious for his discovery of the penicillin…

infection and noticed she had major improvements and made a full recovery. However penicillin was discovered in a much more different way. Bacteriologist Alexander Fleming discovered germ-killing properties in a secret “mold juice” secreted by penicillium. That would spread to the wound and clean it of the bacteria. He could not produce enough of the penicillin to be used by others so his idea was dismissed. Ten years later another scientist rediscovered his works and brought it to the U.S.…

antibacterial effects when he left a culture plate with Staphylococcus aureus, a deadly bacteria, in his lab while he went on a holiday (Ho). When he returned to his lab, he found that there was a clear halo surrounding growth of a yellow-green mold named Penicillium notatum that had accidentally contaminated the plate (Ho). The Staphylococcus bacteria had grown all over the plate, except the area surrounding the mold growth. Fleming would deduce that the mold released an active ingredient,…

Aspergillus aculeatus, Aspergillus niger, Aspergillus oryzae , Penicillum expansum ,penicillium funiculosum, Trichoderma harizanum, Talaromyces thermophiles etc (Torres, Gonçalves et al. 2010) Procedure: We can produce GOS using above mention microbes. But here we use Aspergillus oryzae beta galactosidases for production of GOS, immobilized…

Fleming had been culturing colonies of Staphylococcus when one of the plates, untreated by Lysol, had been contaminated by Penicillium notatum. Fleming observed that the growth of staphylococci had been inhibited in the area immediately surrounding the mold, suggesting that the mold secreted an antibacterial compound (Figure 3). The compound was isolated in 1939 through alumina…

wakefulness and induce a more drowsy state. As a result, the mutant tan fly experiences a delayed reaction when exposed to light (John R. True). A noticeable similarity in amino acid sequence was found between the penicillin produced in fungus Penicillium chrysogenum and the tan gene. The isopenicillin enzyme N-acyltransferase (IAT) is self-activated at the Glycine-Cysteine chain to produce two subunits that interact together; similarly, the tan gene also replicates this method. The last step of…

Bacteria are a fundamental part of life on our planet, but they can also cause disease in our species. People have been using antibiotics for many years, but for the first time they are causing problems. Several years ago, it was discovered that some antibiotics has created strains of bacteria that are resistant to that antibiotic. One example of this is MRSA, or methicillin-resistant Staphylococcus aureus. This means that sick patients must find a different antibiotic or have no way to cure the…

ESKAPE pathogens are six organisms that bring a huge threat to human, because they are drug-resistance. Scientists have not found antibiotics that are effective since the pathogens are multi-drug resistance. Multi-drug resistance is top three on global public health that are mostly caused by nosocomial infections (hospital-acquired infection caused by bacteria, fungal and viral, parasites and other pathogens). The six pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella…

Medicine has been around since the 20th century and is still in use today. Antibiotics are a type of medicine that helps stop infections caused by bacteria. The first Antibiotic (Penicillin) was discovered by Alexander Fleming in 1928. Since the discovery of Penicillin many other antibiotics have been discovered. The development of antibiotics was an important innovation because it cured infections, treated patients during World War I with infections and burns that led to the development of…

had been maintained at Oxford. Chain found it was an enzyme which attacks a specific bacterial structure. While reviewing the literature on lysozyme, Chain came across the paper by Fleming, published in 1929, describing the chance discovery of a Penicillium mold that apparently dissolved pathogenic bacteria in its vicinity. Chain also found a culture of Fleming’s mold in the School of Pathology. In 1941 it was considered that there was enough penicillin for a limited trial in patients at the…