Partition coefficient

Figure 5. Rosiglitazone (highlighted in green) forms three salt bridges with neighboring atoms at the hydrophilic end of the LBD. Rosiglitazone binding to PPARγ causes a conformational change within the complex that causes the dissociation of the endogenous ligand and the recruitment of a nuclear receptor coactivator 2, NCoA-2. This similarly occurs in the other half of the complex: RXRα Receptor A type II nuclear receptor as well, RXR-α heterodimerizes with PPARγ. The ligand that…

Abstract. The theoretical treatment of the equilibrium structure of the derivatives was based on the DFT method using the functional B3LYP with the base 6-311 ++ G (d, p). To distinguish the molecular electrostatic potential surface (MESP), we used the principle of HSAB (Hard Soft Acid and Base), in order to have the centers of activity of a molecule and the effects of substitution on the systems of pyrazolooxazine. These have anti-inflammatory activities. In our work, we have applied methods of…

1 Introduction Berberine (BBR), an isoquinoline alkaloid (Fig. 1), is isolated from many medicinal herbs, such as Coptidis rhizome (Coptis chinensis Franch.) and Cortex phellodendri (Phellodendron chinense C.K.Schneid.) (1). BBR has been used to treat microbial infection, diarrhea, and other gastrointestinal (GI) diseases due to its antibacterial, antidiarrheal and strong antidotal properties (2, 3). In recent years, much focus has been put on its other potential bioactivities, such as…

Chapter 1: Introduction 1.1 Nature of the Dissertation Identification, quantification and analysis Amoxicillin and Flucloxacillin Sugar free antibiotics which are manufactured at Athlone Laboratories by high liquid fluid chromatography (HPLC). The project also involves Method Transfer validation by analysis Amoxicillin Sugar Free for the new project of GSK Mayenne France, this involved Identification, quantification and analysis of carrying Amoxicillin Trihydrate API and Sodium Benzoate in…

The extraction with 10% ethanol in DCM was repeated four times, as opposed to one large extraction, because multiple extractions produces a greater yield of extracted product as explained by the partition coefficient.2 To deter-mine which solvent was best to use to run the column chromatography, TLC was used. Three TLC plates containing annatto extract, a more concentrated spot of annatto extract, and 1 stand-ard were run in three different solutions of…

Adipic acid is mainly use as monomer in manufacture Nylon 6/6 fiber, plasticizer, grease, polyurethane etc. There are several countries in the world that manufacturing the adipic acid. But there also countries that just is a supplier for this adipic acid to any factory that need adipic acid in their countries. The main countries that produce adipic acid are United State of America and also China. Almost ninety percent of adipic acid manufactured in United State of America is used to produce…