Paclitaxel

Ovarian cancer (OC) is the fifth-leading cause of deaths relating to cancer, with less than half of all patients surviving for more than 5 years following diagnosis. It affects women of all ages, most commonly diagnosed after menopause and aged between 55-65 years, 75% of whom are diagnosed at an advanced stage of the disease. Risk factors include age, hormone therapy, and most notably genetic syndromes, such as BRCA1 mutations which are involved in 10% of OC cases. This essay will present the…

“The research team determined that the chemotherapy drugs paclitaxel and gemcitabine cause a molecule called hypoxia-inducible factor1 (HIF1) to snap into action, which in turn starts a process that ultimately produces more breast cancer stem cells” ( Mendes ). When having triple negative breast cancer, it is resistant…

drugs have been developed. For instance, active loading of the amphipathic weak acidic or basic drugs in empty liposomes can be used to increase the encapsulation efficiency. However, active loading is not suitable for hydrophobic drugs such as paclitaxel for which encapsulation efficiency is < 3mole% mainly due to the low affinity of drug for the lipid bilayers.91, 95-97 4. Lysosomal degradation: One of the major limitations of active targeting using ligand-directed immunoliposomes has been…

This paper will examine the medicine and healing techniques of the Native American people and the historical context behind the use of these medicines. It will attempt to uncover the healing properties of traditional herbal medicines as well as the spiritual power to heal human pathologies. Specifically the paper will examine the healing properties of natural remedies including nutritional and spiritual practices used by the indigenous peoples of North America and how those practices might…

respectively. There will probably be continued and extended use of platin-containing regimens with the new generation of molecularly targeted therapies, as exemplified by the recent approval of bevacizumab in combination with carboplatin and paclitaxel in patients with lung cancer; breast cancer provides additional possibilities. Improved tumour-delivery strategies and co-administration with specific modulators of prevalent platin-resistance mechanisms might also provide future clinical…

96 Aqueous One Solution Cell Proliferation Assay Kit (Promega of USA). All cells were plated overnight in 96 well plates with a density of 5,000 cells per well in 100 µL appropriate growth media overnight in a 96 well plate. The cytotoxic drugs (Paclitaxel, ACIN, AMIN), ACIN/COS NPs, AMIN /COS NPs, ACIN/COS-SMCCGGRGDSK NPs, and AMIN/COS-SMCC-GGRGDSK NPs were added to the wells at drug concentration equivalent to 30 µM for the free drug or the drug loaded NPs. The cells were incubated at 37 oC…

Introduction Vincrestine is a plant alkaloid, obtained from the Madagascar periwinkle cathanthus roeus. Before it was used for cancer treatment, the natives of Madagascar used it for the treatment of diabetes and high blood pressure. Structure of Vincrestine: Vincristine has two monomer alkaloid parts, catharanthrine and vindoline, with a formyl group on the indole nitrogen of the vindoline skeleton. Formula C46H56N4O10 Disease it Targets: Vincristine is used to treat various types of cancer.…

in favour of chemoradiotherapy arm. Furthermore, there were no significant difference in the frequency of chemotherapy whether weekly or 2-4weekly. The chemotherapies regimen used were carboplatin/cisplatin combined with either, vinorelbine or paclitaxel. As expected, treatment related toxicities grade 3 and 4 were worse in CRT arm versus RT alone; also it was noted increase in the…

1. Describe 3 targets of antibiotics, why each target is unique to the particular bacteria, and under what circumstance the bacteria could be resistant to that particular drug. (5 pts) As the name implies 50s subunit protein synthesis inhibitors such as erythromycin inhibit protein synthesis by binding to the 50S subunit of the 23S rRNA molecule of the bacterial ribosome. This ultimately acts to block the exit of the growing peptide chain. It should be noted that gram+ bacteria more…

ABSTRACT Dex-Ibuprofen–polyethylene glycol (PEG) conjugates (PEG-dex-Ibu) were organized and their prospective as a prolonged release method was investigated. PEG-Dex-Ibuprofen conjugates were synthesized as of Ibuprofen and PEG with 4000 Da molecular weights by esterification in the incidence of DCC and DMAP. The PEG-dex-Ibu conjugates were characterized by FT-IR, 1H NMR, and DSC analysis. The solubility revise in aqueous system showed an improvement within the solubility of conjugates. The…