Paclitaxel

Current studies have found that taking omeprazole (prilosec) in combination with paclitaxel, will increase the effectiveness of paclitaxel as an anti-cancer agent. Paclitaxel is an effective form of cancer therapy that treats various kinds of cancer from ovarian to lung cancer. Paclitaxel works by promoting the polymerization of microtubules and prevents depolymerization to have a cytotoxic affect on cells (DeAngelis LM, et al., 1995). Omeprazole is a proton pump inhibitor used clinically for gastritis that inhibits V-ATPase and increases the cytotoxicity of chemotherapies such as paclitaxel (Bae DS, et al., 2015). The metastasis of cancerous cells is known to be the leading cause of mortality in cancer patients. Cancer cell progression and metastasis occurs when the cancerous cells are able to…

Bristol-Myers Squibb overall performance positions them as one of the world’s largest bio-pharmaceutical leader. The company business level, functional level and corporate level strategies assisted with overpowering their challenges. The qualitative research method conducted provides a generalized aspect of the company internal weakness, strengths, threats and opportunities the company encountered. The weaknesses shown occurs in the leadership and decision making due to loss of patent protection…

Bristol Meyers Squibb is a pharmaceutical company, with a very rich tradition. This analysis will begin with a few historical highlights. Edward Squibb was a doctor in the Navy, who was unimpressed by the medicine that the Navy was using during the Mexican War, he was so dissatisfied that he threw all of the unfit medicine overboard. On 1858, when he returned, he went on to start his own company in Brooklyn, New York, with the goal of having pure medicine for the people. Squibb’s medicine was…

Overview: The combination of many issues such as prescriptions cost, patients’ economic status, and lack of health insurance, interfere with the patients’ access to their medications. This creates an environmental problem that puts patients at a higher risk for morbidity and mortality, and consequently, increasing the healthcare cost of treatments on health complications due to non-medication compliance (Duke, Raube, & Lipton, 2005, p. 726). Approximately 50 million people in the United States…

Figure 2.1.3 TPGS concentration and Paclitaxel solubility are directly related. Figure created by M. Varma, 200522. TPGS has been incorporated into various drug formulations partly because of its ability to overcome multidrug resistance (MDR). By inhibiting P-glycoprotein (P-gp) activity, the relative cytotoxicity of drugs such as doxorubicin, vinblastine, and paclitaxel was increased19. P-gp is a drug efflux pump, a.k.a. multidrug resistance protein 1 (MDR1), located in the cell membranes of…

with cancer which suppress the mitotic spindles causing mitotic arrest and eventually cell death. In multiple cancers, changes in microtubule stability, isotype expression, and post-translational modifications have been reported. These changes are associated with resistance to chemotherapy and poor prognosis in solid and hematological cancers. Recent research shows that tubulin proteins play a role in cellular stress responses, thus conferring survival advantage to cancer cells.8 Paclitaxel…

The Effect of Manufacturing Processes on Tree-Based Medicine Trees can be used to make a wide variety of drugs and medicines – anything from Aspirin or chemotherapy products to ecstasy. What would happen if someone was to switch the processes to manufacture two types of medicine though? One prediction is if you took a yew tree and processed it in the same way that the mreah prew phnom tree is processed to make ecstasy, you will not get chemo medicine. The independent variable is the processing…

Problem Polymeric nanoparticle to treat Breast Cancer: Abraxane, Albumin-based nanoparticle loaded with Paclitaxel. Introduction Cancer in general is when abnormal cells start growing out of control. These abnormal cells have gone through a mutation in the genome and have lost their ability of growth checkpoint. This means the cells had changes in their DNA and instead of repairing the damage or dying, it continues to divide thus leading to cancer because of faulty cells. The damage to…

into how much medicine the patients receive. Use of docetaxel can result in low white and red blood cell counts. This increases chances of infections and may cause anemia. Other side effects of the drug can be hair loss, weight loss, nausea, vomiting, low platelet counts(increases chances of bleeding), mouth sores, fatigue, etc. Docetaxel is from the drug class taxane. Taxanes are diterpenes. Diterpenes is a class of chemical compounds made of two terpene units. Terpenes are a large and various…

drugs, including paclitaxel. It was suggested that since resveratrol and paclitaxel can modify different regulatory proteins involved in apoptosis and cell cycle regulation processes when used in combinations. Resveratrol strongly diminishes pacilitaxel's anticancer actions; the experiments which were done previously showed that whether resveratrol could sensitize MDA-MB-435s cells (a human breast cancer cell line) to the anticancer actions of Pacilitaxel in vitro. Resveratrol did not enhance,…