Osteoblast

These cells have a single nucleus and responsible for bone synthesis. A group of osteoblasts can produce an osteon, a fundamental unit of a bone. Osteoblasts produce a matrix of osteoid, an unmineralized portion of the bone matrix, and mineralize it using minerals, such as copper, sodium, and zinc. Osteoclasts are cells that break down bone tissue during bone growth and repair. They work with osteoblasts and osteocytes, cells buried in an osteoid, to form the components and structure of bones…

Osteoclasts and osteoblasts are responsible for breaking down bone and replacing resorbed bone respectively (Seriolo et al., 2013). Natural aging results in less bone formation from osteoblasts causing more bone resorption and therefore negatively impacting skeletal homeostasis (Seriolo et al., 2013). Hormones such as estrogen and parathyroid hormone are…

clots from forming. Evidence: A study was done in China to determine how heparin affected osteoblasts. They treated human osteoblasts with heparin to see how they were effected. They found that treating the osteoblasts with unfractioned heparin significantly inhibited their growth. It was discovered that heparin did this by inhibiting the expression of FGF2 and HPSE, two important proteins for osteoblast growth. Source: Xia J, Sheng W, Pei L, Li N, Zhang Z, Wang J, Zu J, Wang N, Wang D.…

cartilage composed of dense irregular connective tissue, and vascularize it. The increase in nutrients resulting from near blood vessels cause mesenchymal cells, stems cells of connective tissue, to differentiate, or change into different cells call osteoblasts. Then, the hyaline cartilage model begins to develop a rough covering around the diaphysis of the long bone, the periosteal…

the other hand, oxytocin deficiency does not affect bone resorption; instead it inhibits the resorptive function of the osteoclasts that is stimulates (Colaianni, Sun, Zaidi and Zallone 2015). Oxytocin from the peripheral nervous system stimulates osteoblast formation which makes it very important for basal skeletal homeostasis (Zhu, DiBenedetto and Greco 2009). During the last phase of pregnancy, females lose about 120 grams of calcium from the skeleton. This calcium is transferred to the…

Osteoporosis is very common in the world we live in today. About 54 million Americans are diagnosed with this disease. Osteoporosis is a bone disease that cutbacks bone mass. The bones become very brittle and frail and are unable to support your weight and usually fracture. The bones that are most likely to fracture are your hips, spine, wrist, shoulder and hip. The bones could become so weak that even if you were to cough or bend over they would fracture. As you grow your bones make new bone…

SUMMARY OF CASE STUDY Bill, a 34 year old male, arrived at the doctor’s office experiencing pain in his right hip. Prior to this, Bill maintains an overall healthy lifestyle which includes exercising and activities such as; swimming, water skiing and scuba diving. Bill reports he has had no trauma to his hip. On this visit an analgesic and muscle relaxant were both prescribed to the patient and he was sent home. After three weeks of no improvement Bill has returned to the doctor’s office and has…

healing. (Marsell, 2012) One of the consequences of this can be the formation of cones or cavities in the gaps. These cavities can be later filled by bone that is produced by osteoblasts. This allows for the simultaneous regeneration of a bony union and restores the Haversian systems. The bridging osteons made by the osteoblasts later mature by remodeling into lamellar bone which then results in a successful fracture healing without periosteal callus…

of calcium in the plasma allowing remodeling and growth of the bone. Parathyroid hormones (PTH) are released from the main cells of the parathyroid gland when calcium levels are too low. The PTH also affects osteoblast cells that are contained in the bone. However, binding of PTH to osteoblast inhibiting it resulting in osteoclast cells being indirectly stimulated through the inhibition of bone building. The parathyroid hormone will act upon collagenase enzymes to increase the breakdown of…

The addition of new bone tissue is known as ossification. It is carried out by osteoblast which are the bone forming cells. Osteoblast began by laying an “organic matrix formed from collagen into the area of new bone formation. Mineralization takes place over a period of days to weeks, leading to finalized bone tissue. This bone is remodeled to match the shape…