Vincristine is the primary treatment for acute lymphoblastic leukemia (ALL) in children. Common toxicities include peripheral and autonomic neuropathies, which can be life threatening. Vincristine is metabolized extensively by CYP450 3A and its PK has a significant inter-individual variation. In addition to chemotherapy treatment, children are given antifungals for prophylaxis of infections. Itraconazole, voriconazole and fluconazole are commonly used agents. The azole family is an inhibitor of…
Reflection essay #4 Our discussion about relationship between creativity and spatial reasoning reminds me of a study of “Mozart effect” (Rauscher et al. 1993), which showing that music by Mozart can temporary improves experimental subjects’ spatial reasoning ability comparing to the control group. Of course, the study is not promoting Mozart’s work. Some recent work shows that the music with seizure frequencies close to the working frequencies of brain can help with stimulating brain activity.…
The Infinity POM By: Vinayak Prathikanti, Varun Popli, & Alan Xiao For the second month, we had the Infinity POM, and it definitely made us think a little. The problem said to consider all of the infinite numbers between 0 and 1, then all of the numbers on the number line. Which one of these is the larger infinity? Now before we say anything else, we want to tell you that this is an extremely open ended problem, and that it is very hard to argue one side. While this is true, we…
Measuring of Execution after training: Table No. 1: Details of respondents’ analysis towards measuring of execution after training. Measuring of Execution after training Frequency Percent Valid Percent Cumulative Percent Valid 50% 161 33.3 33.3 33.3 25% 322 66.7 66.7 100.0 Total 483 100.0 100.0 Source: Field Survey INTERPRETATION: The above table no. 1 attempts to conclude that, 33.3% of the respondents opined with regard to measuring of evaluation after training program that 50% of the…
Q1) What type of reinforcement schedule does random drug testing represent? Is this type of schedule typically effective or ineffective? The type of reinforcement schedule that random drug testing represents is the Variable-Interval(VI) schedule of reinforcement. In Variable Interval schedule a response is rewarded after an unpredictable amount of time has passed. This type of schedule is done randomly and is unexpected. The word random used in this case itself represents the schedule. Variable…
As of the 21st century, it is no longer controversial to believe in the existence of extraterrestrial life. While in the 16th century, a belief that life existed beyond Earth and its atmosphere may have led to a public execution (like it did for astronomer, Giordano Bruno), the same belief is held by 54% of Americans today. Given the evidence gathered through advanced space exploration and technology, the scientific community, as well as the general population, is more inclined to believe in…
Much of the world believes that God is nonexistent. Much of society deems the splendor and majesty of creation to be nothing more than a coincidence. In A Designed Universe, author Robert C. Newman, Ph.D., covers four topics: The Right Chemistry, The Right Environment, The Right Universe, and finally, Explaining the Design. In those four sections, Dr. Newman describes the perfection of God’s creation, and how life would not exist had it been created even slightly differently. From the amount…
In late August, the SETI (Search for Extraterrestrial Intelligence) Institute revealed that they had detected a strange signal that was 94 light years away from Earth. During the time of the signal’s discovery, senior astronomer for SETI, Seth Shostak, could only describe the signal as “interesting”. However, he rhetorically asks, “Could it be another society sending a signal our way?” Shostak, like many other scientists who had heard about the mysterious SETI signal, had hoped for signs of…
Table 4.2 System suitability results for Lamivudine, Zidovudine and Nevirapine Parameters Lamivudine Zidovudine Nevirapine Retention time 2.327 2.864 5.608 Area 212473 338930 228426 USP Plate count 2715.09 3350.07 4979.51 USP Tailing 1.38 1.32 1.18 4.3.1.2 Linearity A linear correlation coefficient factor was obtained between the concentrations of Lamivudine, Zidovudine and Nevirapine versus the peak area. The calibration curves were linear for concentrations between 15-150 µg/mL. The linearity…
6.5 Granger Causality Granger causality statistics determine whether past values of one variable helps to predict another variable. For example, if the lagged value of the independent variable X, help in predicting the value of the explanatory variable Y_(t+1), then X granger causes the Y. On the other hand, if the independent variable X does not help to predict Y, then the coefficients on the lags of X will all be zero in the reduced form Y equation. 7. Empirical results 7.1 Optimal lag…