NMR spectroscopy

flavanoid skeletons. This study focused on the synthesis of chalcones bearing O-, C-prenyl and chromane as substituents. The target compounds were purified by chromatographic methods and structures of all compounds were determined by using IR, NMR and MS spectroscopies. The prenylated precursors were synthesized initially from 2,4-dihydroxyacetophenone (65) and 2,4,6-trihydroxyacetophenone (93). Prenylation of 2,4-dihydroxyacetophenone using prenyl bromide had successfully gave…

occurring when I added the Lucas reagent. For my IR spectrum, I have confirmed C-H stretches at absorption levels of 1,370, 970, and 985. An O-H absorption occurred around the 3,000-3040 vibration making indications that there was an alcohol present. My NMR gave triplet and singlet multiplicity occurring from approximately 1.0-3.5 ppm. Those data points are in correct correlation with the indications of…

synthesized by the reaction of p–[1–(p–hydroxyphenyl) methylcyclohexyl] phenol with methylcyclohexanone, epoxidation with epichlorohydrin followed by addition reaction with acrylic acid. All synthesized compounds were characterized by 1H-NMR, 13C-NMR and FT-IR spectroscopy. Several UV-curable formulated solutions were prepared separately by mixing the prepolymer, BISCHDA (75%), diluent, tri (ethylene glycol) diacrylate (TEGDA) (25%) and different concentrations of a photoinitiator,…

and develop spectroscopic methods to study biomolecules. Prof. Gabriela Schlau-Cohen has caught my attention, with her research on using single-molecule and ultrafast spectroscopies to study photosynthetic and membrane proteins. Prof. Mei Hong's studies of influenza M2 proteins and plant cell walls using solid-state NMR spectroscopy align with my interest in determining the detailed structures, mechanisms and physical principles of biomolecules. My other desire is to develop tools that enable…

of a benzyl ester Knorr pyrrole using various organic reactions (Figure 3), while using mass spectroscopy (MS), thin-layer chromatography (TLC) and proton nuclear magnetic resonance (HNMR) to track the development of DHP. After the coupling of DHP into the tripyrrole, I plan on using various starting materials to adjust the functional groups to find the most suitable variant of tripyrrole by using NMR, TLC and MS to detect potential collapses in the molecule. Although we have a theoretical…

CHAPTER 4 RESULT AND DISCUSSION 4.1 Preparation of Bis-Thiourea Derivatives The mixture of heptanoyl chloride and ammonium thiocynate with 1,4-phenylene diamine appeared as homogeneous solution. White precipitate was formed immediately when the solution was filtered into the beaker containing ice cubes. Then, the precipitate was filtered again and rinsed by ethanol before being dried in the desiccator. The physical data of the synthesized bis-thiourea derivatives are shown in Table 4.1.…

(µij≠0) and a magnetic (mij≠0) transition dipole. Both can lead to absorption of radiation, the intensity of which is directly related to the oscillator strength f, fij≈| µij |2+ | mij |2 In CD spectroscopy, in contrast to an electronic absorption (where electronic dipole >> magnetic dipole) spectroscopy, both transition dipole moments are important. Therefore, an integral of CD (Rij) band is proportional to the scalar product of 2 dipoles: Rij≈ µij * mij (both should be vectors) Rij is…

It has been a little over two months since I began my out of the classroom experience in the Shustova Chemistry lab. With many extractions, separations, Schlenk line setups, and NMR spectroscopies, I am feeling much more confortable preforming higher-level chemistry techniques all while upholding national safety standards. This sense of comfortableness did not come quickly. This is where the most challenging aspect of the Capstone Project comes into play. The challenge that I face when I go into…

producer. Conversely, when researchers used mass spectrometry on the sample, they found that part of it had an unusual molecular mass of 1,242 Da. This portion of the sample was isolated and the structure was looked at closer through the use of NMR spectroscopy and advanced Marfey’s analysis. Through these techniques they were able to find out that this now isolated part of the molecule is a depsipeptide and that the molecule is composed of enduracididine, methylphenylalanine, and four D-amino…

learn. It is this dynamic side of science which I want to be involved in. During a conference at Reading University, I saw how spectroscopy is used in an academic research setting, and then saw the application of the techniques at the research and development site of the pharmaceutical company, Eli Lilly. Of the three echniques we have studied, I find interpreting NMR spectra particularly interesting, as I have an analytical mind and enjoy the logical challenge. I find the connections between…