Neuromuscular junction

This causes the release of acetylcholine in the vesicles into neuromuscular junction. Acetylcholine is an excitatory neurotransmitter that binds to the acetylcholine receptors on the muscle, This opens the sodium channels that depolarize the muscle fiber. Depolarization of the muscle continues along the membrane and then down…

Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare, neuromuscular junction autoimmune disease. The immune system produces immunoglobulin G antibodies against voltage-gated calcium channels (VGCC) residing on the cell membrane of the presynaptic nerve ending.1,3,5,6 The etiology of LEMS is decreased exocytosis of the neurotransmitter acetylcholine from presynaptic neurons into the neuromuscular junction (NMJ) caused by autoantibodies attacking VGCCs.3,7.10 There are two distinct groups of LEMS…

Cases: 1. A 13-year-old male presents with a two-year history of progressive weaknesses in both upper and lower extremities. He finds it difficult to lift heavy objects off a shelf. When sitting on the floor he has to hold onto objects such as a chair to pull himself up. On examination, there is significant wasting of muscles in the shoulders, upper arms, and hips. There is significant weakness on muscle testing (i.e., the patient is unable to exert a normal force with muscle contraction). On…

muscles are located and Sclerosis means scarring. These translations give people a better understanding of what ALS affects. ALS affects the motor neurons in the spinal cord and brain which means that Amyotrophic Lateral Sclerosis affects the neuromuscular system of the body. ALS affects the muscles in the body and eventually the…

Important components of the neuromuscular junction where muscle innervation occurs include muscle and nerve fibres and motor end plates (Dhoot et al., 2013) whereas a neuron itself consists of a cell body or soma, axon, basal and apical dendrites (Megias et al., 2001). Neurons can be classified…

There are many different types of training methods. Skeletal muscle is needed to complete each type of approach. However, depending on the specific training being done, the skeletal muscle will adapt differently to each type. The two most basic types of exercise are endurance and resistance training (Knuiman, 2015). The goal of endurance training is to improve aerobic power by conducting submaximal muscular contractions. Adversely, resistance training involves approximately maximal contractions…

Lab 3: Stimulus strength vs. muscle force production Introduction: The goal of this lab is to determine the relationship between stimulus amplitude (strength) and the contractile properties (i.e. force) of the frog gastrocnemius muscle. Skeletal muscle is composed of bundles of muscle fibers called myofibers. These fibers are themselves composed of myofibrils, which are comprised of the ordered arrangement of actin and myosin. These proteins slide past each other in the presence of calcium…

caused by abnormalities in genes that interfere with proper production of protein to form healthy muscles for voluntary movement. When the brain sends signals to a muscle to contract, it goes through the spinal cord and peripheral nerves to the neuromuscular junction, releasing the chemical acetylcholine that triggers muscle contraction. From here, transportation of the chemicals produced from the reaction of acetylcholine go through muscle fiber membrane and the muscle contracts or relaxes.…

This enlargement fusion and absence of TRPML1 cause lysosomal storage disease (LSD) Mucolipidosis type IV (MLIV). MLIV is an inherited LSD that is known for causing neurodegenerative disorders with corneal opacity, achlorhydria, and impaired neuromuscular junctions which causes skeletal muscles to waste and…

routes) • Magnesium sulfate: 1- 4 g IV/IO over 3 minutes, followed by a 2 g/h IV drip (maximum of 30-40 g/day). This drug is an electrolyte that reduces the striated muscle contractions and blocks peripheral neuromuscular transmissions by reducing acetylcholine release at the myoneural junction, it manages seizures in pregnancy (eclampsia) and causes uterine relaxation. Explain the meds you chose to use and whether or not they cross the placental barrier Present any risks with the fetus in the…