Neurodegeneration

long been recognized as a frequent accompanying up to 10-45% of PD patients, in fact, there have been several case reports of depression preceding the onset of PD. It has became clear that PD can have a prodromal stage, a period during which neurodegeneration has begun, but motor signs permitting classical diagnosis are not defined. Studies have suggested that depressive symptoms may precede motor symptoms in 30% of patients and the relationship between depression and subsequent PD appears to be…

Hence, I hope I could study deeper about neuroscience using zebrafish in neurodegeneration and regeneration research by joining the MSc Integrative Neuroscience at the University of Edinburgh. I acknowledge that Edinburgh is a renowned world leading research university which has a one-of-a-kind Master by Research program in Integrative Neuroscience. This program has fascinating elective offering specialized in neurodegeneration and regeneration including disease modelling and cell repair which…

I. Question: Do polyphenols prevent dementia? II. Introduction: As the elderly population continues to grow, dementia is becoming more prevalent around the world today.1-3 According to Alzheimer’s Disease International, the number of dementia cases is expected to increase from 47 million in 2015 to 135 million by 2050.1 Currently, there is no cure or effective therapies available for dementia. However, vast scientific literature provides significant evidence that addressing modifiable risk…

Huntington disease What is Huntington disease? Huntington disease is an inherited neurologic disorder characterized by progressive neurodegeneration resulting in abnormal movements (chorea), sustained postures (dystonia), psychiatric symptoms, and dementia. The condition most frequently affects individuals during mid-life, but patients range from childhood to age 80. Symptoms are typically insidious – they come about slowly and progressively. Chorea is described as a dance-like, rapid,…

The evolution of amphetamines has seemed to produce a negative influence on current society and our world today. This occurred from the minor influence amphetamines began with as an ancient Chinese herbal remedy, but with the strong biological influence it produced and a change in chemical properties to a synthetic based drug amphetamines have produced more negative turmoil for users. The influence of amphetamines have in society can also be attributed to the natural greed of those producing it,…

It has been hypothesized that this elevation in MAO-B is what contributes to the neurodegeneration observed in PD. In 2008, Mallajosyula et al,. tested this hypothesis by conducting a study in which they induced elevated expression of human MAO-B in the astrocytes of adult mice. The results of the study showed that within 2 weeks of inducing…

correlation between these two conditions. A recent study has linked Schizophrenic and Toxoplasmosis indicating the infection to be causative agent in the increase of dopamine in brain of infected subjects (28). However Toxoplasmosis with respect to neurodegeneration has not been studied as much. Most of the studies that have studied the link between toxoplasmosis and AD are scattered (29, 30) and have seroprevalnce data (31). From our analysis we find that the AD cholesterol and immune system…

Deep brain stimulation (DBS) is a surgical procedure used to treat a variety of disabling neurological symptoms, most commonly symptoms, of Parkinson’s disease. This specific procedure is used to treat individuals whose symptoms cannot be controlled my medication alone (Breit et al, 2004). DBS uses a surgically implanted, battery-operated medical device called an implantable pulse generator (IPG) to deliver electrical stimulation to specific areas in the brain that control movement, thus…

Extra Credit Article Assignment The research paper “Inflammation Animal Models for Schizophrenia” conducted by the department of Psychiatry at Ruhr University summarized research on the neurodevelopmental hypothesis for the origins of schizophrenia. The neurodevelopmental hypothesis states that the neurotransmitter imbalances seen in schizophrenia could be caused by a residual effect of maternal immune responses. The researchers would explain that the immune response of the mother would affect…

Brassica oleracea L. Acta Universitatis. 74(1): 5-13. Tatton WG, Chalmers-Redman RME, Elstner M, Leesch W, Jagodzinski FB, Stupak DP, Sugrue MM, Tatton NA. 2001. Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling. Advances in Research on Neurodegeneration.…