Necrosis

Introduction Necrotizing Fasciitis is known as a “flesh-eating” bacterium that can destroy skin, fat, and the tissue covering a person’s muscles. Studies have shown that there are many different factors that come into play for contracting this disease and multiple risks that can put someone at a higher chance for getting it. In addition, there are various treatment options depending on the severity of the condition and different outcomes. This infection, although rare, can be extremely helpful to a Public Health professional’s career and their goal of educating the public and spreading awareness in order to achieve a healthier lifestyle. Background Necrosis of subcutaneous tissue and fascia is a condition called Necrotizing Fasciitis, or…

This is a gradual and progressive condition that is rarely caused by an infection (Greenfield 2015). Tissue ischemia may form coagulative necrosis, which is a sign for dry gangrene versus a liquefactive necrosis that indicates wet gangrene. The affected area becomes dry, cold, and eventually turns purple or black due to a lack of blood flow to that part of the body (Goodman 2015). Dry gangrene typically affects the distal extremities, thus it is usually seen at the patient’s fingers or toes.…

Typical clinical signs of V. vulnificus infections include fever, chills, diarrhea, nausea, vomiting, septic shock, and characteristic skin lesions [15]. These characteristic skin lesions include lower extremity cellulitis with ecchymosis and bullae. Since the organism can cross the intestinal mucosa rapidly, development of bullous skin lesions of the lower extremities can occur within the first 24 hours after onset of illness [16]. This onset if often thought of as an early manifestation of…

Necrosis occurs as a result of external injury due to cellular injury, bacterial toxin or trauma to a particular area of the body. Necrosis differs from apoptosis in a couple of ways. First, the morphological changes that a cell undergoes are different in necrosis compared to apoptosis. Secondly, apoptosis is highly regulated, however, necrosis is unregulated. The morphological changes that a cell undergoes during necrosis are the swelling of the cytoplasm, irreversible damage to the plasma…

components into surrounding tissue (121). Key players that help mediate necrosis include ROS, Calcium ions, poly-ADP-ribose-polymerase (PARP), and lysosomal proteases (888). PARP is an enzyme that is responsible for repairing DNA damage, such as strand breaks. Cells that have undergone a traumatic cellular insult typically have damaged DNA. PARP will deplete cellular ATP in an attempt to repair the massive damage to DNA. Several proteases are activated by increased cellular calcium ion…

Discussion Question #6 Article Summary My research paper is about a cytokine --- Tumor necrosis factor alpha, which is involved in systemic inflammation and is found in high concentration in patients diagnosed with autoimmune disorders. The article chosen describes the effects caused by a change in the level of cytokine Tumor necrosis factor-a (TNF-a). The cytokine TNF-a is a proinflammatory, recognized to encourage HIV-1 reproduction and is involved in the development of HIV-1 related…

“But most of the research and most of the cranial deformation has been focused on wooden boards and bandages. That’s when you get the most extreme deformation,” (Okumura 2010:3-4). One of the most dramatic methods was putting a large stone on infant’s head. According to anthropologists, the stone often caused avascular necrosis to infants. Avascular necrosis is the death of bone tissue due to a lack of blood supply. Also called osteonecrosis, avascular necrosis can lead to tiny breaks in the…

Avascular necrosis is when your bone tissue collapses and breaks down and eventually dies due to the lack of blood supply that it gets. The Age group that the disease mostly common in is 41-60. How can you tell you have this ? We will analyze a lot of the key factors in the disease. What kind of symptoms you have during. Do people who have diabetes or cholesterol are more prone to this disease? A Lot of questions will be answered in this brief presentation. Age wise this disease is focused on…

Fractures to hip, hip dislocations along with some other hip traumas can destroy blood vessels and harm the movement the femoral head in the skeleton. Femoral head, which is the highest part of the femur head, is the site where avascular necrosis commonly occurs in the skeleton along with knees and hip in the skeleton. According to Cure search for children’s cancer, avascular necrosis usually affects the long bones ends such as the femur bone, which are the thighbone by causing problems in the…

mentioned the pain could now be found in his left hip as well. His doctor decided to draw blood work and send for x-rays and made several realizations. The x-rays showed that there had been a change in Bill's right thigh bone that tipped him off into believinjg Bill was suffering from avascular necrosis. Avascular necrosis is when the blood supply is cut off from a part of a bone and consequentially, the tissue dies. The doctor believes this may have occured because of Bill's scuba diving hobby.…