Nanoparticle

Rats along with mice make up about 90% of the animals used in research today. Due to both rats and humans being mammals, they share a variety of similarities in structure and function. Thus making rats ideal candidates for research in laboratories along with them being easy to care for, handle and reproduce. Rats are physiologically, genetically and morphologically closer to humans than other research animals. Rats are used for research in a large variety of human conditions from diabetes and…

that bind to T-cells as well as presentation of antigen on MHC-I and MHC-II is critical. Only one study was found that looked at DC activation with CpG conjugated via the 3’ and 5’ end. Beaudette et al conjugated CpG via the 3’ and 5’ end to a nanoparticle and reported a non-significant, on average 10 % increased CD86 expression and IL-12 production in bone marrow-derived dendritic cells (BMDC) stimulated with 3’ conjugated CpG compared to 5’ conjugated CpG 33. In order to directly compare and…

CRP was identified from patients with acute pneumococcal pneumonia at the Rockefeller Institute for Medical Research (Tillett and Francis, 1930), a name that reflects its reaction with the C-polysaccharide of Pneumococcus. This pentameric protein with MW 118 kDa has five non-covalently bonded and non-glycosylated identical subunits of 206 amino acids each to form a disk-shaped pentagon (Fig. 1). CRP has been proven as an early indicator of infectious or inflammatory conditions as well as a…

be needed, such as repeated intracerebral injections, which will cause both a high risk of complication and a resistance of further vector interaction [Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles]. Besides, non-viral vectors needs modifications to pass the blood brain barrier(BBB), though the transduction efficiency is still relatively…

Pallavi V. Pople and Kamalinder K. Singh. 2006. Development and Evaluation of Topical Formulation Containing Solid Lipid Nanoparticles of Vitamin A. AAPS PharmSciTech. 7 (4) Article 91 29. Pinto E, Pina-Vaz C, Salgueiro L, Gonςalves MJ, Costa-de-Oliveira S, Cavaleiro C, Palmeira1A, Rodrigues A and Martinez-de-Oliveira J.2006. Antifungal activity of the essential oil of Thymus…

EMPLOYMENT, RESEARCH, VOLUNTEER, & EXTRACURRICULAR EXPERIENCES Paid Employment #1 Supervisor, pharmaceutical recruiter As a team leader of scientific recruiters, I was able to utilize my leadership skills and recieved exposure to the job requirements of various clinical professionals. I led a team of recruiters and offered conceptual knowledge of the terminology used in clinical environments. The companies which I staffed for included: Novartis, Biogen, Bayer, Abbott, and Exedra. I learned a…

CHAPTER 2 LITERATURE REVIEW 2.1 Synthesis of Schiff base Method preparation for Schiff base ligand is a straight forward synthesis and easily modified using different amines and carbonyl compound. This could be one of the reasons that make Schiff base ligand popular in coordination chemistry research. Synthesis of Schiff base ligand commonly, taking place in alcohol through condensation reaction of amines and carbonyl compound. The acid/base catalysis or heating is employed in the synthesis…

existing polymer product line. This would not only benefit the company but would also increase clients’ product satisfaction. Incorporation of different nanoreinforcements such as layered silicate clays, carbon nanotubes, nanofibers and silica nanoparticles into elastomers significantly enhances their mechanical, thermal, dynamic mechanical and barrier properties. Noticeable improvements in adhesion, rheological and processing behaviour can also be seen. (Anandhan & Bandyopadhyay, 2011).…

Neuroblastoma and microRNA- 34a is commonly mentioned together in many articles and studies around the world. With the advance in medicine and new discoveries, there has been found a dependence relation of neuroblastoma with these specific type of microRNA since it has been discovered how it could eliminate cancer eternally. MicroRNA-34a has not only revolutionized scientists but the world in general because of its ability to destroy neuroblastoma but also because is a new natural genetic…

To study the tolerability of the analgesic autoinjector in the non-rodents( rabbit) by analysing biochemical parameters. 8.1 Introduction The objective of drug discovery and drug delivery system is to treat infections and particularly pain and suffering during the ailments and thereby maintaining a healthy human population. Any development in medical field is evaluated using a variety of clinical procedures prior introducing to humans. In pharmacological research, animal usage has become a…