N-terminus

The protein that is in sequence one is Alpha-synuclein. Alpha-synuclein is a protein whose function in the healthy brain is currently unknown (Alpha-synuclein and Parkinson's Disease, n.d.). Parkinson's disease researchers take great interest in it because it is a major constituent of Lewy bodies, which are protein clumps that are the pathological hallmark of Parkinson’s disease (Alpha-synuclein and Parkinson's Disease, n.d.). Researchers work to characterize the protein's role in Parkinson’s and its potential as a target for neuroprotective therapies (Alpha-synuclein and Parkinson's Disease, n.d.). For a very small subset of Parkinson's patients, hereditary variability in the alpha-synuclein gene contributes to developing the disease (Alpha-synuclein and Parkinson's Disease, n.d.). In these rare cases of familial Parkinson’s disease, the alpha-synuclein gene produces either too much alpha-synuclein protein or an abnormal form of the protein (Alpha-synuclein and Parkinson's Disease, n.d.). Parkinson’s symptoms vary from person to person and early signs of Parkinson’s disease may go unnoticed. These symptoms include a tremor, slowed movement, rigid muscles, impaired posture and balance, loss of automatic movements, speech changes, and writing changes. As many as one million Americans live with Parkinson's disease, which is more than the combined number of people diagnosed with multiple sclerosis, muscular dystrophy and Lou Gehrig's disease (Statistics on Parkinson's, n.d.).…

expect to see a reduction in the viral titer in the DF-1 cells that are stably expressing viperin compared to the DF-1 cells that are transfected with an empty vector. Objective 4: Identification of the critical regions and residues important for duck viperin function and localization. Viperin consists of three distinct domains; an N-terminal domain that varies considerably between species and contains both an amphipathic helix and a leucine zipper domain; the N-terminal domain plays an…

The full name of EHBP1 is "EH domain binding protein 1." The symbol for the gene is EHBP1. Other names for the EHBP1 gene are HPC12, NASCIN, and KIAA0903. EH Domain Binding Protein 1 is a protein coding gene. This gene codes for an Eps15 homology domain binding protein. Its protein type is a vesicle. The encoded protein may play a role in endocytic trafficking. It is associated with prostate cancer. This gene is commonly found within the cytosol and the plasma membrane of a cell. It's size is…

Sequence one’s protein was found to be apolipoprotein E. This protein is known as the APOE gene. The protein forms molecules called lipoproteins by combining fats in the body. Lipoproteins have the responsibility to package cholesterol and other fats, and send them through the bloodstream. To prevent disorders with this protein, it is important to maintain the right level of cholesterol, so that it does not affect the heart and blood vessels that could causes a heart attack, stroke, or a…

What impact has TM Landry had on me? An impact is the way an outside force influences an individual’s behavior. Everyone has experienced an event that has shaped their beliefs or influenced their actions. These events can vary from a death to moving schools. This was the case with Sean. Sean waited at the bus stop as he replayed the last two weeks. Sean’s dad had recently moved them to a different state for his new job. Since Sean was an introvert, he dreaded the idea of starting over in…

I had got use to having the skytrain doors shut in my face. No matter how confused or scared someone looked, no one had the time to stop or help a lost person. The ride back home seemed to be longer than usual and I could not help but notice the nervous group of kids trying to figure out the directions. Looking at them reminded me of the time when I first used the skytrain without any adult supervision. I vividly remember the struggle my little cousin and I faced just to get back home. It…

Colorado a place where there are beautiful snowy mountains and a bunch of scenery. A girl from Los Angeles, California that would be the weirdest thing to imagine for someone who grew up around beaches and warm weather all the time. That girl was me, I just learned that I was moving from sunny California to bi-polar weather Colorado. Learning that I was moving to a completely different state was one of the hardest and weirdest things for me. During the months of September and October my…

For my service project I did two types of volunteering. One was being the president of Kilmer's Student Council Association (SCA). In SCA, a group of seventh and eighth grade students, including myself, got together about every other week, for an hour, to discuss, plan, and promote student events. Some of these events included student dances, holiday/seasonal games at lunch, fun runs, fundraisers and Kilmer Spirit Week. First, we would discuss what materials and how much time we would need to…

Clendinnen recounts the history of the Yucatan peninsula once the Spanish arrived. She splits her recounting into two sections: the Spanish’s perceptive and the Mayan’s perspective. Clendinnen’s recounting the Spanish side of history demonstrates a struggle not only between the Spanish and the new land and its inhabitants, but also the internal conflicts between the Spanish settlers and the friars. At first she tells us how the Spaniards’ interactions with the natives consisted of tribute…

Have you ever heard the saying, “wrong place, wrong time,” or maybe that life is about “being at the right place at the right time”? Or have you ever heard about the cartels and their crimes down in Mexico? Murders, kidnapping, drug trafficking, and lots of partying goes on every day by every cartel and by every drug lord south of the border. Unfortunately, these two topics have much in common in Mexico. Civilians that do not have anything to do with the cartels get caught up in these kind of…