Mutant

gene mutation that occurs in ACVR 1 alters stem cells ability to differentiate into the specific types of tissues or cells that are needed to repair injuries and replace cells (Kaplan, Nassau, & Shore, 2014). This causes stem cells to express the mutant receptor that only triggers cells that replace cartilage and bone. Therefore, it overproduces bone where it is not needed, leading to Fibrodysplasia Ossification…

RESEARCH STRATEGY (a) Significance. Yersinia pestis (Yp) is a Gram-negative bacterial pathogen that is the causative agent of plague. Yp is a Category A agent defined by the National Institute of Allergy and Infectious Diseases (NIAID) as a pathogen that is high risk to public health and national security. A long term goal of NIAID is to explore the host-pathogen interaction and host response to infection with Yp, and to identify and characterize immune responses after exposure to Yp (1).…

In the second part of “Wonder” we read in Via’s point of view. Via’s point of view tells how, Auggie, got this deformation. In part two there is a chapter called Genetics 101, and a chapter called The Punnett Square. In these two chapters we read the possible of Via and Auggie having the chances of getting kids like Auggie. In this part it tells the same days Auggie is having in part one, but the way she is seeing and living the days. In the first chapter of the second part, Via tells us that…

Alkaline phosphatase catalyzes the hydrolysis and transphosphorylation of phosphomonoesters (1). A kinetic reaction scheme of AP is presented in Figure 2. Figure 2: Kinetic reaction scheme of alkaline phosphatase (11). Under the hydrolysis reaction, free phosphate and an alcohol molecule are released from the active site. The rate-determining step of this reaction is pH dependent. Transphosphorylation has similar initiate steps as hydrolysis. However, phosphate cannot exit the active site,…

This summer I had an internship working in Paul Garrity’s behavioral biology lab at Brandeis University and conducted experiments on genetically modified common fruit fly, Drosophilia. There I learned about the important research that is being done on these fruit flies throughout the country and the burgeoning science of genetic modification that has begun dominating laboratories across the country. This research focused in on the sensory receptors that the flies use to detect changes in…

To illustrate, how Science can aid lives with their new improved technology; however, they can harm lives with the defects, or flaws, of their technology. With it stands, Dracula presents blood transfers that can save lives, but also loses lives if not done right. Next is Dr. Jekyll and Mr. Hyde presents potions, or in other words pills and medications that help mental illnesses to separate both good and evil; however, it brings in the side-effects of these medications. Finally, Maximum ride…

Marvel and DC Comics have had a friendly rivalry since the 1930s starting from the comic books and now going into the movies. DC characters are heroes and demigods among humans. Their stories tell how they use their powers to fight crime and that they are heroes because their superpowers. Marvel characters are the opposite they were created not as heroes but as relatable normal human beings with problems and normal stories. Their character development is about how they deal with their…

their function and substrates have been elusive. Zheng et al. demonstrated that human ALKBH5 protein efficiently catalyzes demethylation of m6A containing RNAs. Utilization of iron by ALKBH5 protein during catalytic reaction seems to be critical as mutant version (H206A or H266A) of iron center in ALKBH5 protein compromised its demethylation activity. Furthermore, the depletion of ALKBH5 increased the m6A level and accumulated poly[A]-tailed RNA in cytoplasm, causing sterility in male KO…

The mechanisms of evolution are mutation, gene flow, genetic drift and natural selection. These mechanisms are based upon the changes that occur within an organism’s gene pool and how they affect those organisms and their survivability. Some of these mechanisms of evolution move quickly and affect large populations while others are slow moving and affect small populations. Not all of the evolutionary mechanisms are positive and benefit the population’s long term survival. Commonly these negative…

Recombination and mutation are the motivation of evolution. Recombination is critical for repairing DNA lesions and for chromosomal pairing, and exchange during meiosis (Krejci et al. 2012). Recombination does not occur uniformly on the chromosomes of eukaryotes. Meiotic recombination in well studied yeast revealed that non-uniformity of recombination was observed when the frame of reference is an entire chromosome, multigene region and a pair of genes or a small region upstream of a gene…