Mutant

Research Experience Metabolic Integration in Salmonella enterica: My first research experience began with a summer internship in the Bacteriology department at the University of Wisconsin, Madison, investigating the compensatory mechanisms involved in metabolic integration. The overarching goal was to identify the changes and alternative pathways required to sustain life in a Salmonella enterica strain whose thiamine (vitamin B1) biosynthetic gene, thiH, had been replaced by an equivalent…

Inverse agonism has great potential as a possible therapeutic treatment option in the future” Inverse agonism: Inverse agonism is phenomenon associated with G-protein coupled receptor (GPCR), in which inverse agonist binds to the same receptor as an agonist but induces an opposite pharmacological response to the agonist. For inverse agonist response the receptor must have an intrinsic activity in the absence of any ligand1,2. How inverse agonist act? According to the two state receptor theory,…

Joseph Strorm is shown as religious and strict father to David. Firstly, Joseph shows his true character in moments of concern when David asks for an extra hand. One evening, David had reached home and noticed a splinter in his hand which he pulled out but continued to bleed a lot. He was given assistance from his mother who helped him clean up the wound and neatly striped it up, as she finished helping her son, then David claims mentioning he could have managed on his own if he had a third hand…

on the Caenorhabditis elegans worm, where they first identified a process of programmed cell death (apoptosis), essential for their development, by the that a defined number of cells produced initially in excess is eliminated. Through studies on mutants of these worms, the genes necessary for this process were identified and their homologs have been found in…

This mice is usually bred as a mutant type considering the sparse way of catching it in nature. Being a furred mammal, it has hair all over at different lengths and fibers to aid in keeping a sustainable environment (Dry 1926). Most of the adaptive thermoregulation in a mouse takes place…

The system allows researchers to easily create many animal models of diseases that were previously found to be difficult to do because creating these models was slow and costly. The system could be used to correct mutant genes that cause genetic disorders, getting rid of the disease overall. In 2014, a study was done by scientists at MIT in which the CRISPR/Cas9 system was used to cure mice of a rare genetic liver disorder. There are a wide variety of other genetic…

Using a specific example discuss a possible target for the development of anti-mycobacterial therapeutics ATP synthase is a main enzyme used to produce ATP in respiration of a cell. It makes use of a proton gradient in the mitochondrial cell membrane to generate ATP. By transporting protons back across the membrane, using ADP and a phosphate ion to create ATP. Normally most bacteria can gain enough ATP to grow optimally through substrate level phosphorylation, however it has been shown that M.…

to a transgenic tobacco plant. Once again, through the use of overexpression, the tobacco plant showed an increased photosynthetic rate and increased product yield. Being introduced into the plant’s chloroplast, the mutant gene had a much higher yield than the wild type gene. The mutant gene tobacco plant had increases in dry weight, photosynthetic rate, and Rubisco efficiency.…

In and around the world exotic animals are getting traded by the millions. When this happens pet keepers need to be guilty for doing nothing about it. In the 1980’s exotic turtles became popular due to the “Teenage Mutant Ninja Turtles” show. When a request comes in for an exotic animals on the black market the animal is often times just plucked out of their habitat causing extreme stress that can lead to death. If humans continue to do this many animals will go…

Common tumors are often caused by mutations in the genes that may potentially lead to varying protein structures, which do not correlate with their proper functions (1). Majority of these mutations arise as a result of substituting one nucleotide base pair for another, but a significant number are also from adding or removing one of more of these nucleotides that ultimately disrupts protein translation (1). One of the mutated genes linked to cancer is BRCA1 (2,3,4). BRCA1 stops tumor growth by…