1. INTRODUCTION Warfarin is a most common Anticoagulant in prevention and treatment of thromboembolic events despite the availability of new drugs such as Novel Oral Anticoagulants due to its affordability. The establishment of the International Normalized Ratio (INR) helps to guide the dosing requirement for patients receiving the warfarin therapy. However, over-anticoagulation leads to adverse events such as haemorrhage while thromboembolic events can happen even at a recommended dose.…
method, and how enzymes are affected by temperature. Introduction Proteins which constitute enzymes in their final form are macromolecules that make up large amounts of living organism which are called polymers which are made up of many different monomers. An enzyme is a biological catalyst that increases the rate of a reaction by lowering activation energy. Activation energy that the enzyme uses id an energy barrier that must be overcome before a chemical reaction can proceed (Lecture, 4/28).…
Introduction The predominant disease that mutant FGFR3 (fibroblast growth factor receptor 3) gene causes is Achondroplasia. Furthermore, Achondroplasia means the absence of chondrocyte formation in bones. Additionally, the transformation of chondrocytes into bone cells is prevalent in the limbs as well as the facial bones of humans (1). Therefore, the predominant symptom of Achondroplasia is bone growth retardation and is found in the limbs as well as facial bones. The majority of people…
determined nor measured at this time because those are factors falling under the quantitative data range. Q2. Hair is made up of Keratin. Sulfurous amino acids, biotin, and vitamin A are all examples of protein which keratin supports. Carbohydrates have monomers, which are organic compounds within keratin. Nucleic acids represent identical polypeptides, as a form of cytoskeletal keratin expression. Lipids are fats within keratin. How much of it, numerically, is inconclusive at this time. There…
Polyimide is a polymer of imide monomers. Polyimides have diverse applications in areas demanding rugged organic materials such as high temperature fuel cells, displays, and various military roles, due to their high heat resistance. A typical polyimide named Kapton is synthesized by condensation…
Important aspects for polymers and conjugated drugs A choice of anticancer drugs have been conjugated with polymers, including anthracycline antibiotics, antimetabolites, platinum analogues, alkylating agents, as well as peptides, proteins and enzymes (Meng, and El-Deiry, 2002). The main requirement for a candidate drug in this field is the drug minimum effective concentration. For example, if the minimum effective concentration needs to be ~10 '3 M for a drug with a molecular weight of -50 kDa,…
FPV is in the family Parvoviridae, which contains 26 species of virus that infect a broad host range, covering species from invertebrates to humans. Parvoviruses are small single stranded DNA viruses enveloped by a T=1 non-enveloped capsid protein. Replication of these viruses can only occur when the host cell is in S-phase of its mitotic cycle (15). FPV has a very small linear genome that is only 5 kilobases in length (4). The virus’s genome has specific sequences, similar to a TATA boxes, that…
Sickle Cell Disease Throughout the world, approximately 300 million individuals are heterozygous for a mutation in the β-globin gene, meaning they carry the sickle cell trait (Key, Connes, & Derebail, 2015). Of those 300 million individuals, 100,000 Americans are affected by sickle cell disease, making it the most common inherited blood disorder. Every single cell in our body needs oxygen to function efficiently, and the role of hemoglobin in red blood cells is to transport oxygen from the lungs…
2.1. C. tomentosum extract characterization C. tomentosum extract proximal composition is shown in Table 1. The relatively higher ash proportion in seaweed extract (SE) (aprox. 74%) could largely be accounted for by the lower moisture content, and probably due to a hygroscopic nature of the SE (Blanco-Pascual, Montero, & Gómez-Guillén, 2014). The values of TPC and DPPH radical-scavenging activity are consistent with literature (Andrade et al., 2013; Valentão et al., 2010) (Table 1). POD and PPO…
An infection happens when a foreign organism attacks a human body. There are different types of organisms that can cause us harm, for example; Viruses, Bacteria and Fungi. Not all infections are the same; some are mild while some can end up being life threatening. Also, infections can be contagious; they can be transmitted by a variety of ways, for example; skin contact, airborne particles, touching an object that an infected person has touched. One of the very common and effective ways to…