Monoclonal antibodies

to target plaques in the brain. Scientists want to target plaques by possibly recruiting the immune system. The idea is to stop beta-amyloid from clumping into plaques and also clear beta-amyloid from the brain. Research is being done with a monoclonal antibody called solanezumab and so far it seems to be effective. It seemed to be more effective when it was given earlier in the course of the disease like patients with mild Alzheimer’s (Alzheimer’s Treatments: What’s on the Horizon?). Drugs…

drug development starts with identification of the rug targets. These targets may be recep0tors, enzymes, transporters, ion channels etc. 8000 drug targets were estimated after sequencing the human genome. Among the 2392 actually acted upon for antibodies and 794 for drug proteins. These targets are known to exhibit various polymorphism. For instance, the polymorphism of B2 adrenoceptors which was discussed earlier producing responders and non responders phenotypes. Sometimes these various…

6. Quantitative determination of rat peroxisome proliferators activators γ (PPAR-γ): Rat PPAR-γ concentration was determined by ELISA; using a commercially available kit, MyBioSource, Inc., California, USA. The kit utilizing a monoclonal anti- PPAR-γ antibody and an PPAR-γ-HRP conjugate enzyme-linked immunosorbent process assay (ELISA) to determine the concentration of PPAR-γ in serum, plasma, urine, cell culture supernatant and tissue homogenates. Principle of the assay: The sample and buffer…

Coronavirus comes from the family of coronaviridae, they are pathogens found in birds and mammals. Coronaviruses is a positive sense RNA virus and it was classified into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, Betacoronavirus. There are many human types of the virus, for example, MERS-CoV, and SARS-CoV. SARS-CoV is a Severe acute respiratory syndrome. The Severe acute respiratory was found in 2003 when it first hit China and caused a big outbreak. Studies have shown…

Since this syndrome encompasses multiple phenotypic characteristics and difficulty in treating/ supervision, it is crucial to have patients be set with a multidisciplinary team, that consists of nurses, radiologist, pathologist, audiologist, otolaryngologist, geneticist, ophthalmologist, neurologist, and lastly a neurosurgeon (1). The ideal way to manage these patients through early detection, making sure patients/ populations at higher risk are screened, patients are monitored, and determining…

the results are still inaccurate (“Animals in Science – The Failure of the Animal Model”; M.P.H., “Why Animal Experimentation Doesn’t Work – Reason 3”; “Animals in Science – The Failure of the Animal Model”). A therapeutic antibody to monkeys, called anti-CD28 monoclonal antibody TGN1412, triggered a potentially fatal immune response for people (“Animals in Science – The Differences Between Humans and the Animal Model”). One scientist’s opinion on the relatively similar genetic makeup between…

Nursing Care Under Chemotherapy Desensitization Cancer itself is a difficult situation. The cure for cancer hasn’t still been discovered. It attacks the body in various parts and unfamiliar ways. Not only that it affects the person that has cancer, it also affects the people that surround that person. Some people have survived cancer and this is because there are treatments being developed to help cancer patients in battling their illness. The article, “Nursing Care of Patients Undergoing…

significant change to the platelet count that has been established to be 10 µM. Such was confirmed by the flow cytometry that exhibited the highest increment in larger platelets, with increase ranging between 10 and 20 µM of ADP. However, 20 µM could not be used because it would cause excessive aggregation. Platelets contained in population 1 (P1) area are all of the same size as that of the resting platelets and they are assumed not to be activated. Whereas, the platelets in population 2 (P2)…

Kristin Fitzpatrick BI 456 Immunology Disease Term Paper 11/21/14 Systemic Lupus Erythematosus: Epidemiology, Diagnosis, and Treatment Options I. INTRODUCTION Lupus, Latin for “wolf,” originally referred to the erosive facial lesions that resembled a wound from a wolf’s bite. In the Middle Ages lupus was mainly described as a dermatologic condition. It was not until 1872 that lupus was considered a systemic disease that presented with subcutaneous nodules, arthritis, lymphadenopathy, fever,…

The authors indicate that since the 1980s. The explosive increase in knowledge of the cell and mediator mechanisms of asthma has only led to modest improvements in therapy including the introduction of leukotriene modifiers and a blocking monoclonal antibody against IgE. Indeed, biologics targeting allergic cytokines and effectors cells that have on the whole proven disappointing despite initial promise being shown in animal…