Mitochondrion

Sensitivity of Cancerous C.elegans with Mitochondria Dysfunction Mitophagy is a selective autophagic elimination of damaged or excessive mitochondria, especially when cells are under adverse stress. Mitophagy has been identified as the cause of various human diseases and even cancer. In recent years, researchers gradually regard mitophagy as the target for cancer treatment, although the role of mitophagy in the developmental and metabolic process of cancer is still not clear. In this…

Alkylated polycyclic aromatic compounds (alkyl-PACs) are the major aromatic constituent of total PAH in crude oil and originated from incomplete combustion process. Whereas benzo[a]pyrene (BaP) is a well-known human carcinogen, dibenzothiophene (DBT) and retene (Ret) are not; however, all three compounds are important environmental pollutants. Their toxicity is not yet characterized. In this study, we used BaP (parent PAH), DBT and Ret (alkyl-PACs) to elucidate the mechanism of neurotoxicity…

The researchers used two groups of rats: one fed the ketogenic diet regimen and the other a control diet. They found that chronic ketosis resulted in the increased production of mitochondrial proteins as well as proteins associated with oxidative phosphorylation, the cells primary mechanism for producing ATP. The researchers used electron micrographs from the dentate-hilar region of the hippocampus, and visually analyzed the micrographs from ketogenic diet fed rats and control diet fed rats.…

Question and Hypothesis Experiment I Eukaryotic cells contain several membrane-bound organelles. Plant cells are a specific type of eukaryote that are both aerobic and photosynthetic. Because of this, they contain mitochondria that serve a vital role in aerobic respiration that follows photosynthesis. The enzyme succinate dehydrogenase (SDH) is an enzyme associated with the Citric Acid Cycle that takes place in the mitochondrial matrix. SDH serves as a catalyst for a reaction in which succinate…

Rigor Mortis The term rigor stems from the Latin term meaning stiffness. Mortis stems from the Latin term meaning death. Upon death, respiration ceases to occur. Without oxygen, metabolism stops, organs shut down. The body’s main source of energy is the cell production of ATP. Wikipedia’s definition:” Adenosine triphosphate (ATP) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical…

Riboflavin contains a tricyclic dimethyl-isoalloxazine ring (Flavin Nucleus) that is conjugated to a 1-Carbon ribityl, an alcohol derived from pentose sugar D-ribose, is attached at the 9 position of isoalloxazine nucleus as shown in Figure 1. The metabolically active coenzymes of riboflavin are riboflavin -5-phosphate or Flavin Mononucleotide (FMN) and flavin adenine dinucleotide (FAD) that participate in many vital oxidation reduction processes. Catalytic sites of some enzymes are covalently…

succinyl-CoA synthetase, succinate dehydrogenase, fumarase, malate dehydrogenase, and citrate synthase. The Cori Cycle has many parts to it ultimately leading to the breakdown of glucose and the diffusion of lactate with the liver. In the Cori cycle there is the conversion of glucose to lactate through anaerobic glycolysis in muscle cells, the diffusion of lactate from muscle cells into the bloodstream then being transported to the liver. To the conversion of lactate to glucose through…

Making ATP from Free fatty Acids:- The other two energy substrates, FFAs and AAs, bypass glycolysis and ultimately enter the TCA cycle/oxidative phosphorylation as pyruvate, acetyl CoA, or different components of the TCA cycle. FFAs are released from adipose tissue by lipolysis and circulate in blood bound to serum albumin. Transport proteins then translocate FFAs into cells. FFAs are metabolized in mitochondria by the repetitive, cyclic process of β oxidation. This requires the transport of…

Organelle Failure Nucleus: The nucleus of a cell is, without doubt, one of the most important parts of the cell. The nucleus instructs every single part of the cell what to do, and what the different organelles need to do. The nucleus includes chromatin (protein and DNA). It also contains Nucleolus (nucleoli is plural). These nucleoli are responsible for ribosome production. If the nucleus were to suddenly malfunction, this would mean that the cell would have no directions, and nothing to…

Many endosymbiotic theories have figured in opinion about the differences between prokaryotic and eukaryotic cells. More than 20 different versions of Endosymbiotic theories have been presented in literature to explain the origin of eukaryotes and their mitochondria (Martin, Garg and Zimorski, 2015, p.1678). A Prokaryotic cell contains structural components such as: Cell wall is made of peptidoglycan. Gram-positive bacteria contain a thick cell wall with many layers of peptidoglycan…