Introduction: LC-MS is used for the bioanalysis of small molecules drugs, which has molecular mass of less than 800 Da. Now a days, it is also frequently used for the bioanalytical determination of biopharmaceuticals.1 In pharmaceutical R & D, it takes a year to develop a new marketing drug identified from thousands of new compounds. The drug discovery is divided into early and late phase, during which pharmacokinetics study or bioanalysis of a drug is done. Once, the bioanalysis of a drug is…
Hydraulic fracturing in other words fracking is a technique used to extract natural gas from rocks. In the deeper layer within the earth, about 7000 feet below, rocks like shale contains gases, water and oil in their pores. Drilling companies carry out a horizontal drilling to the rock layer along with a traditional vertical drilling to create new routes or to extend the existing pipes for the extraction of natural gas. They allow these gases to escape by injecting a fluid under high pressure…
Costus speciosus (J.König)sm is a widely used medicinal plant in Ayurvedic medicine. Scientific literature prove about various therapeutic properties of its rhizome and leaves. The effectiveness of Costus speciosus (J.König)sm leaf aqueous extract on reversing insulin resistance was studied and data were published previously. This study was designed to evaluate the dose-response relationship of Costus speciosus (J.König)sm leaf aqueous extract. Insulin resistance induced rats were treated with…
Xanax Samantha E. Mendoza San Joaquin Valley College Xanax The brand name is Xanax, the generic name is alprazolam, and the chemical name is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4] benzodiazepine. It is a drug used for managing anxiety disorder or for the short term relief of anxiety symptoms in adults (WebMD, n.d.). Xanax is considered a Schedule IV narcotic because Xanax has a medical use, but the drug is still considered to have potential for abuse. It belongs to a class of…
The developed method consisting the mobile phase 3g of Docusate Sodium was dissolved in 580 ml of Methanol, sonicated to dissolve to this 420 mL of milli Q water was added and pH was adjusted at 3.0 with perchloric acid with isocratic programming, XTerra RP 18 column (250mm×4.6mm, 5μm) column as stationary phase with a flow rate of 1.0 ml/minute. Proposed…
In vitro aerodynamic performance testing using Next Generation Impactor™ (NGI™) The aerodynamic behaviour of the spray dried powders from the Aerolizer® device (Novartis, Surrey, UK) was assessed using the Next Generation Impactor (NGI; Copley Scientific, Nottingham, UK). NGI setup comprises of a stainless steel induction port attached with a mouthpiece adaptor, eight removable stainless steel collection cups located at seven plus a micro orifice collector (MOC) stages, a high capacity vacuum…
Are diet cokes healthy for you just because they have the word ‘diet’ in them? Well, the answer to that question is no. Studies have shown that diet coke can actually damage your body incredibly. It can make you lose your body structure as well as make you gain weight. Most people see the word diet and see the calories of the beverage and assume that it is healthy for you. However diet coke can make you gain weight instead of lose it. Researchers have found that diet soda drinkers’ waist grew…
The previous lab that was conducted dealt with oxidation, which is referred to as a compound gaining oxygen or losing electrons (Wyman, 2015). This week’s lab consisted of a reaction that was the opposite of an oxidation and it is known as a reduction reaction. To be more specific a reduction reaction is when the reactant that is present gains electrons, which is response lowers the overall formal charge of the compound. For instance, if there are two hydrogen ions and each one has a positive…
ϖ This task is done by Mohammadmehdi(Mehdi) Adhami for PBL Definitions: alcohol abuse: it is the act of consuming alcohol containing products frequently or inappropriately (e.g. Binge drinking); which might result in short term or long term complications. It is often associated with addictive behaviors and it most likely interferes with person’s normal life balance, including the ability to work and interpersonal relationships. Alcoholism: it is the addiction to consuming alcoholic drinks or…
But, the pesticide is very dangerous. The kids in Ghana don’t wear the protective clothing that they are supposed to. Pesticide has very dangerous chemicals inside like ammonia, arsenic, benzene, chlorine, dioxins,ethylene oxide,and methanol. These are not the only chemicals in the spray, there are lots more and more dangerous too. These chemicals can make you very very sick. They can cause cancer or even worse, you can die from the chemicals inside of the pesticide. The kids are forced…