Metabolic pathway

competition for binding to metabolic enzymes is could be one of the reasons for the observed reduction of genotoxicity with B[a]P with PAHs…

finger millet act as anti-nutrients because of their metal chelating and enzyme inhibition activities but now it has been confirmed that these constituents can contribute to antioxidant activity, which is an important factor in resisting aging and metabolic diseases.Morevoer, finger millet is also useful in management of various physiological disorders such as diabetes mellitus, hypertension, vascular fragility, hypercholesterolemia, prevention of oxidation of lowdensity lipoproteins (LDLs) and…

Zhang et al., found that, metabolic disorders in metformin treated group were significantly improved and the renal lipids deposition and other pathological changes were ameliorated. They also found the increment of expression of phospho-AMP-activated protein kinase (P-AMPK) α protein and the significant diminution of expression of sterol regulatory element-binding protein (SERBP)-1c and TNF-α. They concluded that metformin up-regulated activity of renal AMPK, improved metabolic disorders,…

system dysregulations and system impairments as described below: Cellular and Molecular Changes: at this level accumulating cellular and molecular destruction becomes decisive, because the processes of cumulative oxidative damage form the reasonable pathways resulting in frailty (Aunan, Watson, Hagland, & Soreide, 2016; Clegg et al., 2013; Zaslavsky et al., 2013). In addition, current research has proposed that the hallmarks of cellular damage are genomic…

Results The CNS has an important role in functions of the body with carrying messages to and from the brain and body. Without neuro-messages being transmitted, the skeletal muscles would be unable to move. Therefore, the brain and body need to communicate. “There can be little doubt that the regulation of central motor output is crucial in determining exercise performance” (Hargreaves, 2008, p. 1541). Although with the complexity of the CNS understanding what the role the CNS has to…

People all over the world habitually use oils and fats for their daily cooking, in order to add quick energy and taste, but also to complement their food with certain health benefits. Different oilseeds and nuts, as well as animal fats, have served as the source for these fats. Among these, palm oil has been historically one of the most commonly used fats in the world. African populations have traditionally relied upon red palm oil and coconut oil, as well as groundnut and sesame oil. Palm oil…

for one hemoglobin, oxyhemoglobin, and deoxyhemoglobin. Oxyhemoglobin dissociation curve is the relationship between hemoglobin saturation and PO2 not linear. The hemoglobin changes shape to facilitate further uptake after binding with oxygen and metabolic needs can change loading/unloading of oxygen. The factors affecting oxygen unloading from the hemoglobin are due to tissue PO2 by activating tissue and decreasing PO2 by releasing more oxygen. Temperature is increased by active tissue and more…

impairment they are seeing in obese children. Lack of sleep can also affect their hormones and leptin which can increase weight gain. Infections at a young age that were treated with steroids in infancy and toddlerhood can cause endocrine or metabolic pathways that can end up causing childhood obesity. Scientist believe that nutrition and physical activity is the biggest factor in childhood obesity. Depending on their lifestyle and diet can make all the difference. Nowadays parents tend to let…

As an adult, we will face uncountable instances of stress or frustration. While certain amounts of stress are considered normal, excessive stressful situations can take a toll on our overall health. Extensive research has been done to show the detrimental effects that stress can have on the body. It can affect sleep habits, the digestive system, heart rate, blood pressure, and can even exacerbate preexisting health problems. Numerous medical and psychological research studies show significant…

GBM tumors biologically present a number of challenges for development of anticancer drugs and their delivery to the tumor site. Perhaps the biggest obstacle is the localization of tumors in the brain, which implies that the anti-cancer agent must be able to penetrate the blood brain barrier (BBB). The BBB is a highly selective permeability barrier that separates circulating blood from cerebrospinal fluid in the Central Nervous System (CNS). It is mainly formed by endothelial cells lining the…