Messenger RNA

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    Prp Scrapie

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    A prion is a infectious protein agent and the specific name of prion in BSE is PrP scrapie(PrPSc). The normal protein that is being acted upon by the protein is called cellular prion protein(PrPc). Prions are a problem because they are an abnormal form of a normal protein that is misfolded without an immune response. The strings of amino acids are put together to make proteins inside cell. Then they are then pushed together and folded into a framework letting them function properly. These prion…

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    Rad8 Research Paper

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    Rad8 is a conserved protein, it was previously reported to be sensitive towards both UV and gamma irradiation during G1/S period in Schizosaccharomyces pombe (Doe et al., 1993). It consists of three conserved domains, including E3 ubiquitin ligase motif, SNF2 helicase domain, and a family specific HIRAN domain. Rad8 is required for error-free post-replication repair by contributing to polyubiquitylation of proliferating cell nuclear antigen (PCNA). Up-regulation (12.52-fold) of Rad8 indicated…

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    Sickle Cell Anaemia

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    the DNA unwinds and unzips leaving the base pairs exposed. Helicase is used in this reaction- the enzyme breaks the hydrogen bonds between the complementary bases. Activated RNA nucleotides then bind with the complementary base pairs exposed where A binds with U, G binds with C- the enzyme which catalyses the reaction is RNA Polymerase. The final mRNA strand which is produced is complementary to the original DNA strand. The mRNA is free to leave the nucleus through the nuclear pore and attach…

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    After reading chapter three I had a better understanding of DNA replication, what genes do, and also how humans are connected to other species, a better understanding on how we are all part of a “biological continuum”. In 1962 three men named James Watson, Francis Crick, and Maurice Wilkins won of the most distinguished award which was the Noble prize. Although one more person also help discover DNA which she was not credited was Rosalind Franklen. DNA replication is the process one strand of…

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    1. a) The three parts of a nucleotide are phosphate, nitrogen-containing base, and the deoxyribose sugar. b) Deoxyribose sugar is the sugar that is found in a nucleotide. c) The nitrogen-containing base is the nucleotide component that contains nitrogen. d) The four nitrogen bases shown in Model 1 are Adenine, Thymine, Guanine, and Cytosine. 2. a) I pointed at a single nucleotide on the ladder model of DNA, on the worksheet. The nucleotide included phosphate, nitrogen-containing base, and…

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    INTRODUCTION Biological ageing, or senescence, is a complex process characterised by progressive functional deterioration and cognitive decline (1). Accumulation of age related changes make individuals more prone to death and disease (2). Understanding these changes is important to understand the complexity of the human lifespan. The Hallmarks of Aging (3), is an article which describes nine factors that contribute to the ageing process. Aggravation or alleviation of these could contribute to…

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    Things All RNA Epigenetics can do: Variegated structural, catalytic, regulatory activities, translation of genes to proteins Variegated RNAs to interact with other cellular machinery (DNA, Proteins, etc.) in specific ways Alteration of RNA structure which in turn, leads to alteration of protein bindings and cellular effects Affect gene expression by activating or silencing it Controls transition from pluripotency state to differentiation, which allows different types of cells to be made and…

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    In sequence 1, the protein that the DNA sequence coded for was Presenilin 2, also known as PSEN2. These proteins are developed from directions from the Presenilin Gene. One of the jobs of PSEN2 Gene is to process proteins that transmit chemical proteins from the cell membrane into the nucleus. From there they can activate genes, critical to cell growth and maturation (What is the normal function of the PSEN2 gene ). Processing amyloid precursor protein is also one of the main functions of PSEN2.…

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    APOE Gene Analysis

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    The APOE gene, located on chromosome 19, is a gene that helps in the creation of apolipoprotein E to help to form molecules called lipoproteins, this protein forms the lipo-proteins by combining with lipids in the body. By forming lipo-proteins, apolipoprotein E participates in the responsibility of managing cholesterol and carrying it, and other fats, through the bloodstream. By maintaining cholesterol, it helps to act as a prevention against disorders that can hurt the cardiovascular system,…

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    Overall Structure (Score 7) Dr. Glaunsinger divided her talk into four main sections over the course of her 50-minute talk. As her introduction, she appropriately began by providing a synopsis of her research by describing the mission of her lab and providing an overview of her interest in the interaction between DNA viruses and the eukaryotic genetic regulatory systems. To emphasize the broad goals of her lab, she introduced examples of model viruses, such as the gamma herpes viruses and MHV68…

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