Messenger RNA

segments of DNA that contain short, repeating sequences. The repetitions are then followed by segments of DNA from the host DNA strand. A simple version, CRISPR-Cas9, has been modified to edit genomes. By delivering the Cas9 with a synthetic guide RNA (gRNA) into a cell, the cell's genome can be cut at a desired location, allowing existing genes to be removed and/or new ones added. CRISPR-cas9 is like a tiny pair of scissors that scientists can control. Once the strand of DNA is split the cell…

Lymphocytic Choriomeningitis virus (LCMV) belongs to the Old World arenavirus family of enveloped viruses (Buchmeier et al., 2007). LCMV in particular has served as model organism from many significant studies in the field of immunology such as the Nobel Prize winning study of the Major Histocompatibility Complex (MHC) by Zinkernagel and Doherty (1975). LCMV’s natural reservoirs are the common household rodents (Traub, 1936). Household mice have shown to attain persistent asymptomatic LCMV…

pancreatic adenocarcinoma[1, 2]. A major hindrance towards development of therapies against pancreatic ASC is that the molecular mechanisms underlying its pathogenesis remain poorly characterized. In this proposal I will take advantage of the expertise on RNA biochemistry and molecular biology that I have acquired during my doctoral training and combine it with the in vivo approaches developed by the Ventura lab to investigate the potential role of non-sense mediated decay and of the UPF1 gene…

First, I would like to say that the topic I chose is very interesting and in fact I really like this topic. Before choosing my topic I had rough idea about what CRISPR was and how it was being used in recent times to engineer everything around us by small steps. Before my research findings I had an idea what CRISPR was such as how it was being used around the world on modifying genes, and engineering new species by deleting or replacing the genes that were unwanted by that organism. What I knew…

Nobel Prize winners James Watson and Francis Crick unraveled the mystery of molecular biology. James Watson and Francis Crick have significantly improved the world with their discovery of the structure of deoxyribonucleic acid, commonly known as DNA. The prodigious work they accomplished in their lives has had a profound impact on modern science. James Watson and Francis Crick deserve to be honored among the list of 100 influential Americans put out by The Atlantic publication. James Watson and…

Electrophoresis Kendra Gibson November 17, 2015 A scientist drops DNA samples in small indentations at the end of a Jell-O-like gel. He turns on an electrical current at the other side of the gel. His anticipation grows as he watches the samples slowly move from one side to the other. He pulls out a ruler and makes some measurements. He steps back in surprise, for he had just identified the most feared serial killer in the world! He did this by using Gel Electrophoresis. Electrophoresis (the…

Scientists have relied on fossilized bones to find out about ancient species. They take lots of information from these bones and find out things including their ear shape, length of their fur, and what they last ate before they died. The genes that are collected are used to show how that certain animal or species lived/survived. Proteins which are found in the cells help perform processes and drive the cells. The work done by these scientists have helped the world to better understand…

1.INTRODUCTION p53, also known as TP53 or tumor protein, is a gene that codes for one protein which stimulates another protein that inhibits enzymes needed to drive the cell cycle and functions as a tumor suppression. It is very important for cells in the role to suppress cancer. P53 has been described as "the guardian of the genome", referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular…

Antisense RNA molecules that target Htt mRNA have been known to impair the translation of the gene sequence into the protein in vitro. However, the process of designing an siRNA which would target the mutant CAG repeat does inevitably result in degradation of normal…

3-2-1 Assignment- Genetic Inheritance 3 Main Points: 1. The cell contains three important things. Those three things are the nucleus, mitochondria, and the ribosomes. The nucleus consists of DNA and RNA molecules which contain hereditary information that has a jurisdiction of the cell’s purpose. The mitochondria contains mtDNA distinctive influence in human developmental research. Lastly, the ribosomes are the basic necessity to the process of protein synthesis. 2. Meiosis is a process where…