Melanoma

if the mole is malignant it will be asymmetrical, and this can be a warning sign for melanoma. The B stands for border. A malignant mole's borders tend to be uneven and the edges may be notched (in the shape of a V). This can also be warning sign for early melanoma. C stands for color. If a mole is one shade (usually brown) it is benign, but if it has a variety of shades or colors, that can be a sign of melanoma. The D stands for diameter. Malignant moles are usually…

cause skin cancer. Skin cancer is one of the most common cancers in the world. The most dangerous skin cancer type is called melanoma. It is a cancer of pigment(color)-producing skin cells. It is caused by both genetic risk factors and UV light from the sun or tanning beds. White skinned people can get this type of cancer more easily but it can happen to anybody. Melanoma happens even after three years you burn your skin. It will make your skin red,…

1.5 Drugs targeting the Rab prenylation pathway 1.5.1 Prenylation pathway Prenylation of Rab proteins is the essential lipid modification step that begins the membrane trafficking cycle. It is a crucial post-translational modification that allows the stable attachment of Rab proteins to the membrane by increasing hydrophobicity to be able to insert into the lipid bilayer (Maltese, Wilson and Erdman, 1996). As depicted in Figure 7, the Rab cycle starts with a Rab protein that is GDP bound, in…

tanning can lead to premature skin aging, immune suppression, and eye damage, including cataracts and ocular melanoma.”(U.S Department of Health and Human Services, 2016) Parents are allowing their kids to use tanning beds at a very young age, which is increasing their chances of skin cancer, premature aging, and immune system suppression. The most famous type of skin cancer is melanoma. Melanoma is most dangerous skin cancer and accounts for death each year. This statement alone should change…

The causes of cancer are observed as multifactorial. This is because there are several traits causing cancer such as genetic, environmental, medical and lifestyle factors. However the knowledge of cancer is rapidly improving, helping everyone to understand and be able to identify at risk individuals, tailoring treatment and developing new methods against cancer.(cancer.gov,2015) Genetic information includes information about an individual’s genes including the manifestation of a disease in the…

Skin cancer is the most common form of cancer in the United States. That is not surprising because the skin is the largest organ of the human body. There are three types of skin cancer basal cell carcinoma, squamous cell carcinoma, and Malignant Melanoma, which is the most dangerous to the human body. The first two are the less common known of skin cancer. It is diagnosed through the detection of lesions on the skin's surface.Pigmented moles on the skin overtime begin to change size,shape, and…

There are three main types of skin cancer that is caused by the abnormal growth of cells within the skin. There is the basal cell carcinoma that starts off in the basal cells, squamous cell carcinoma that forms in the epidermis, and the malignant melanoma which happens when the melanin has become cancerous. Many people around the world have been diagnosed with one of these cancers and has suffered from how it has caused their bodies to change drastically. The basal cell cancer begins in the…

from the epidermis. Is mainly caused by ultraviolet (UV) exposure daily, year-round exposure to the sun’s UV light, exposure in the summer months, and the UV produced by tanning beds all adds to the damage that can lead to squamous cell carcinoma. Melanoma, the most lethal case of skin cancer, is produced in the cells (melanocytes) that produce melanin, the pigment that gives…

since I have previous experience in the inhibition of cell signaling pathways in melanoma, I believe we could establish a productive research relationship. After I earned my doctoral degree in Microbiology, my first postdoctoral appointment in U.S was in the laboratory of Dr. Keiran Smalley at H. Lee Moffitt Cancer Center. Our main objective was to develop novel therapeutic approaches for the treatment of melanoma through the inhibition of cell signaling pathways in cell…

Vemurafenib is approved for the treatment of valine in exon 15, at codon 600 (V600E) mutant metastatic melanoma. It is a small molecule serine-threonine kinase inhibitor, which binds to the ATP-binding domain of mutant BRAF (Luke). These drugs are most effective in malignant melanomas, where NRAS and BRAF have been characterized to drive approximately 80% of lesions (Curtin). Vemurafenib proved effective in melanoma patients with B-Raf mutations with a response rate of greater than 50% and a…